Clinical Research On The Treatment Of Kidney-yin Deficiency Bleeding By The Method Of Tonifying Kidney And Adjusting The Menstrual Cycle And Combined With Low-dose Estrogen And Progesterone Sequential

Purpose:Using traditional Chinese medicine tonifying kidney and adjusting the menstrual cycle combined with low-dose estrogen and progesterone sequential treatment of AUB-O patients,observing the improvement of menstrual cycle,menstrual period,bleeding volume and accompanying symptoms,combined with serum sex hormones and B-ultrasound to monitor follicular development and changes in basal body temperature,explore Chinese and Western medicine Combined with the clinical efficacy and safety of the treatment of the disease,it opens a new path for the treatment of abnormal uterine bleeding,and provides a basis for the clinical application of the law.Methods:Sixty patients with AUB-O who met the inclusion criteria were enrolled.They were divided into observation group and control group according to the principle of randomization.The observation group was treated with traditional Chinese medicine tonifying kidney and adjusting the menstrual cycle combined with low-dose estrogen and progesterone sequential therapy,and The control group was treated with sequential estrogen and progesterone treatment.Both groups were treated for 3 menstrual cycle.The improvement of TCM symptoms such as menstrual cycle,menstrual period and bleeding volume before and after treatment were observed and compared.at the same time,the five serum sex hormones,follicular development and changes in basal body temperature were compared,SPSS25.0 was used for data analysis.Through the results,the clinical efficacy and advantages of the combination of traditional Chinese and western medicine in the treatment of renal yin deficiency abnormal uterine bleeding were evaluated.Results:(1)Clinical efficacy:The total effective rate of the observation group was 90.0%,and the total eff ective rate of the control group was 86.67%.There was no significant difference between the two groups(P>0.05).(2)TCM syndromes:Both groups can significantly improve TCM syndromes.After treatment,the total scores of TCM syndromes in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).The total effective rate of TCM syndromes in the observation group was 93.3%,and the total effective rate of TCM syndromes in the control group was 90.0%.The TCM syndromes in the observation group were significantly better than the control group,and the difference was statistically significant(P<0.05).(3)The main symptoms of menstrual cycle,menstrual period and menstrual flow:both groups of treatment can adjust the menstrual cycle,improve the menstrual period,menstrual flow,the difference between the groups is not statistically significant(P>0.05)(4)Sex hormones:There was no significant effect on the LH and FSH in the two groups.There was no significant difference between before and after treatment of the two groups(P>0.05);E2 levels were increased in both groups,and there was no significant difference between the two groups(P>0.05);T can be reduced,and the difference between the groups is not statistically significant(P>0.05);and the observation group can reduce the PRL level,and the difference between before and after treatment of the observation group is statistically significant(P<0.05).(5)Follicular development:There was no significant difference in follicular development between the two groups during treatment(P>0.05).(7)Basal body temperature:There was no significant difference between the two groups in the treatment of ovulation recovery(P>0.05).Conclusion:Traditional Chinese medicine tonifying kidney and adjusting the menstrual cycle combined with low-dose estrogen and progesterone sequential treatment of AUB-O can effectively improve the menstrual cycle,menstrual period and menstrual flow,can help patients to restore ovulation function,and the improvement of TCM syndrome is better than the control group.No adverse reactions occurred during the test,indicating that the combination of traditional Chinese and Western medicine for the treatment of renal yin deficiency has the effectiveness and safety,which is worthy of clinical application.