Analysis Of Prevalence And Related Risk Factors Of Non-alcoholic Fatty Liver Disease

Objective: To investigate the prevalence of nonalcoholic fatty liver disease(NAFLD)and to explore the risk factors of NAFLD.Methods: A total of 14976 people were selected from the physical examination center of the first affiliated Hospital of Dalian Medical University from may,2018 to November,2018.The total number of patients with fatty liver detected by abdominal ultrasound was 4927,and the prevalence of fatty liver was 32.89%.A total of 701 subjects with complete physical examination data and no long-term heavy drinking history were selected from the general examination population for this study,including389 males and 312 females,with a ratio of 1.24:1 between males and females,aged21-86 years,and an average age of 46.99±11.51 years.The subjects in this study were divided into non-alcoholic fatty liver disease(NAFLD)groups according to whether fatty liver was detected by abdominal ultrasound,and the rest of the subjects with complete physical examination data during the same period without a history of heavy drinking were used as the normal control group.The prevalence of non-alcoholic fatty liver disease among people with complete physical examination data was calculated by stratification of age and gender,and the differences in the prevalence of non-alcoholic fatty liver disease among different ages and genders were compared.Will NAFLD group of age,body mass index,blood pressure,blood sugar,blood lipid,hepatic function,renal function,blood routine,such as test results with the same period has a complete physical examination data of the normal control group,and compare the different eating habits for whether the prevalence of NAFLD has difference,draw a nonalcoholic fatty liver disease related risk factors.Results: a complete physical examination data and there is no history of heavy drinking check-up crowd in a total of 701 people,abdominal ultrasound liver spleen pancreas were detected in patients with NAFLD,249 people,including male 158,female 91,in the study sample population African alcoholic fatty liver disease,35.5%of the total incidence,prevalence of men is significantly higher than female patients(male 40.6%,female 29.2%,P < 0.001);To different age groups and found group of incidence between men and women of NAFLD is different,the prevalence of NAFLD before the age of 25 no statistical difference in gender,36 to 45 years old male overall prevalence,the prevalence of NAFLD has exceeded the crowd was 43.5%,and the men in the prevalence of 46-55 peak(51.8%),while women appears after the age of 46 suddenly rose 31.5%,the highest prevalence at the age of 56-65 and 50.0% more than the male;There was no significant difference in the prevalence of non-alcoholic fatty liver disease between males and females after 66 years old.Univariate analysis of various indicators in the NAFLD group and the normal control group showed body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),and white blood cell count.(White blood cell count,WBC),red blood cell count(RBC),hemoglobin(HB),Alanine Aminotransferase(ALT),Aspartate aminotransferase(AST),γ-Glutamyl Transpeptidase(γ-GT),Uric acid(UA),Fasting plasma glucose(FPG),Low-density lipoprotein(LDL-C),Total cholesterol(Total cholesterol,CHOL),Triglyceride(TG)was significantly higher in the NAFLD group than in the normal control group(P<0.001),creatinine(Cre),urea nitrogen(BUN),platelet count(Platelet count,PLT)There was no significant difference between the two groups(P>0.05),and high density lipoprotein(HDL-C)Significantly lower than the control group(P<0.001).Logistic binary regression analysis of NAFLD-related factors that were meaningful for comparison between groups showed that independent risk factors for nonalcoholic fatty liver disease(NAFLD)included BMI,UA,FPG,LDL-C,and TG,with OR values of 1.163,respectively.1.003,1.219,3.086,2.297.The abnormal rates of overweight,obesity,blood pressure,blood glucose and blood lipids in the NAFLD group were significantly higher than those in the normal control group,and it wasfound that smoking,high-sugar,high-calorie carbohydrate diet,lack of exercise and other unhealthy dietary lifestyle could increase the prevalence of NAFLD.Patients with NAFLD are prone to liver damage,and elevated ALT is more dominant than elevated AST.Conclusion: The prevalence of nonalcoholic fatty liver disease varies among people of different ages and genders.Patients with nonalcoholic fatty liver disease are prone to liver enzymology abnormalities.Poor living habits and related components of metabolic syndrome(Hypertension,diabetes,lipid metabolism disorder,overweight,obesity,hyperuricemia,etc.)can significantly increase the prevalence of nonalcoholic fatty liver disease.