Clinical Efficacy Observation On The Treatment In Children With Henoch Schonlein Purpura Nephritis Of Spleen And Kidney Qi Deficiency Type By Shen Qi Er Zhi Powder

Objective:To observe and evaluate The clinical efficacy of Shenqi Erzhi Powder in the treatment of purpuric nephritis in children with spleen and kidney qi deficiency.Medthods:54 cases of children into spleen Deficiency Henoch-Schonlein purpura nephritis,before and after treatment methods used to study the self-control,Shenqi Erzhi Powder four week course of treatment of 12 weeks of treatment.Included trials in children before treatment,after 4 weeks,8 weeks,12 weeks,recorded the symptom score and urine laboratory,microalbuminuria,24-hour urinary protein excretion index,the symptom score was observed changes in laboratory situations and indicators to evaluate its effectiveness.Liver and kidney function and blood routine were observed before treatment and after 12 weeks of treatment to evaluate their safety.Resultes:1.A total of 54 cases were included in this study.There were 6 cases of shedding,no cases were removed,and 48 cases were actually completed.In terms of overall efficacy evaluation,after 12 weeks of treatment,2 cases were clinically controlled,accounting for 4.17%;25 cases were markedly effective,accounting for52.08%;15 cases were effective,accounting for 31.25%;6 cases were ineffective,accounting for 12.50%;total effective 42 cases,there were always The efficiency is87.50%.Among them,the effective rate of light(mild proteinuria)was 93.33%,and the effective rate of severe(moderate proteinuria)was 75.00%.There was a difference in the effective rate between the two groups after treatment(P<0.05).2.Comparison of TCM syndrome scores: After 4 weeks,8 weeks,and 12 weeks of treatment,TCM syndrome scores were lower than before treatment,and the difference was statistically significant(P<0.05).3.Comparison of single symptom scores of TCM: After 4 weeks,8 weeks,and12 weeks of treatment,the scores of TCM single symptoms were lower than before,and the difference was statistically significant(P<0.05).4.Comparison of laboratory test indicators: Although the RBC index improved but not obvious in the 4th week of treatment(P=0.062>0.05),the difference was not statistically significant.At the 8th week of treatment and the 12 th week of treatment,the RBC index was significantly improved,and the difference was statistically significant(P<0.01).Urinary protein,urinary microalbumin,24-hour urine protein treatment at 4th week,8th week,and 12 th week compared with before treatment,the difference was statistically significant(P<0.01).5.Safety: During the treatment,there were no serious adverse reactions and no abnormalities in liver and kidney function.Conclusions:Shenqi Erzhi Powde has a good clinical effect on the improvement of TCM symptoms in children with spleen and kidney qi deficiency type purpuric nephritis,and has significant effects on urine protein,urinary red blood cell count,urine microprotein,and 24-hour urine protein laboratory index improvement..Shenqi Erzhi Powde was safe and effective in treating the disease,and no adverse drug reactions occurred during the treatment.