Correlation Analysis Of Clinical And Pathological Factors And Prognosis Between Lymphovascular Invasion And Breast Cancer

Objective To investigate the correlation between lymphovascular invasion in breast cancer and other clinicopathological features and its influence on the prognosis of patients.Methods 1.The clinical and pathological data of 341 patients with breast cancer were retrospectively analyzed.The chi-square test was used to analyze the difference in the positive rate of lymphovascular invasion between the groups of clinical and pathological characteristics of breast cancer.2.Univariate survival analysis（log-rank）and Cox regression multivariate survival analysis（Cox regression multivariate survival analysis）were used to analyze whether lymphovascular invasion was an independent prognostic factor of breast cancer.3.Kaplan-meier method and Cox method were used to conduct univariate stratified analysis of lymphovascular invasion according to lymph node metastasis,to analyze the influence of lymphovascular invasion on survival and prognosis under different lymph node metastases.Results 1.There were statistically significant differences in the correlation test between lymphovascular invasion and tumor size,lymph node metastasis,and ki-67 expression（P<0.05）.OR value and 95%confidence interval were OR _{tumor size}=2.038（1.187-3.499）,OR _{lymph node metastasis}=2.415（1.329-4.388）,OR_ki67=2.428（1.122-5.255）,respectively.However,there was no significant difference in the correlation test between age,BMI,ER,PR,her-2,molecular typing and other clinicopathological indicators with lymphovascular invasion（P>0.05）.2.There were statistically significant differences in the correlation test between lymphovascular invasion,lymph node metastasis,tumor size and prognosis and survival of breast cancer patients（P<0.05）.The risk ratio（HR）and 95%confidence interval（ci）were 2.475（1.233,4.970）,2.466（1.204,5.053）,and 1.864（1.030,3.376）,respectively.However,there was no significant difference between age,BMI,ER,PR,ki-67,her-2 and survival prognosis（P>0.05）.3.The average survival time and 7-year survival rate of breast cancer patients in the group with both lymphovascular invasion and lymph node metastasis were 75.0 months and 66.6%,respectively.The average survival time and 7-year survival rate of breast cancer patients in the group without lymphovascular invasion and without lymph node metastasis were 90.5 months and 91.2%,respectively.The mean survival time and 7-year survival rate were84.6%and 86.3 months respectively for breast cancer patients with lymphovascular invasion and no lymph node metastasis.The mean survival time and 7-year survival rate of breast cancer patients without lymphovascular invasion and with lymph node metastasis were 85.7 months and 86.1%,respectively.Statistical calculation results showed that the overall difference in survival rate between the groups was statistically significant（P<0.05）.The risk ratio HR and 95%confidence interval were HR _{stratified lymphovascular invasion}=2.913（1.465-5.792）.Conclusion 1.There was a positive correlation between vascular thrombus of breast cancer and tumor size,lymph node metastasis and ki-67 expression.2.Breast cancer tumor size,lymph node metastasis and lymphovascular invasion are all risk factors affecting the prognosis of breast cancer.3.lymphovascular invasion is an independent risk factor for breast cancer prognosis.