| Objective:The purpose of this meta-analysis was to determine the relationship and quantitatively assess the impact of rs4295627 polymorphism on the risk of glioma.Materials and methods:Data were extracted from Pub Med,Embase and Google Scholator with a search deadline of January 2019.OR and its 95% confidence interval CI were used to assess the impact of CCDC26 rs4295627 polymorphism on glioma susceptibility.Heterogeneity tests and publication bias assessments were also conducted.Results:Significant correlation was observed in the aggregate analysis of all five genetic models.Overall OR was significantly higher than 1,from 1.34 to 1.96(G vs T: OR = 1.37,95% CI = 1.30-1.44;GG vs TT: OR = 1.96,95% CI =1.70-2.27,GT vs TT: OR = 1.34,95% CI = 1.26-1.42;GG + GT vs TT: OR =1.40,95% CI = 1.32-1.49;GG vs GT +TT :OR = 1.78,95% CI = 1.55-2.06).Conclusion:The results of this study clearly showed that the G allele of rs4295627 polymorphism significantly increased the risk of glioma.However,a well-designed large-scale study is needed to further assess the impact of rs4295627 polymorphism on different types or degrees of glioma in different ethnic groups,and to measure the impact of combined effects on the risk of glioma. |
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