Correlation Between Plasma Heat Shock Protein 90α Level And Pathological Features Of Lung Adenocarcinoma

Objective To investigate the correlation between the expression level of plasma heat shock protein 90 a(HSP90 a)and histopathological types and immunohistochemical Ki-67 index in patients with lung adenocarcinoma.Methods A total of 50 patients with lung cancer admitted to the First Affiliated Hospital of Anhui Medical University from 2016 to 2018 were enrolled.The pathological biopsy of the tumor tissue obtained by surgery,percutaneous CT-guided pulmonary puncture or fiberoptic bronchoscopy was first diagnosed as lung adenocarcinoma.According to the IASLC/ATS/ERS classification method of lung adenocarcinoma in 2011,the specific description and corresponding diagnosis of tumor growth pattern were given.The immunohistochemical staining of tumor tissue was performed to determine the value-added index ki-67.Specific values were given.The plasma heat shock protein 90 a level was detected during hospitalization and specific data were available.The erimental results were processed using SPSS22.0 analysis software.Results There was no significant correlation between HSP90 α level and Ki-67 index in patients with lung adenocarcinoma.The correlation coefficient was 0.2,P=0.16.Serum HSP90 α level was correlated with different histopathological classification,x 2=11.93,P=0.018,the difference was statistically significant.Academic significance;there was no statistical difference in the expression of Ki-67 between different histopathological types,chi-square value x 2=5.46,P=0.24.Conclusion Hsp90 a is a commonly used index for predicting the prognosis of lung adenocarcinoma.This study compares the expression level of plasma HSP90 a in lung adenocarcinoma patients with the Ki-67 index and pathological type corresponding to its tumor tissue.The pathological type of lung adenocarcinoma was correlated,but not correlated with tumor tissue proliferation index Ki-67.This conclusion can guide us to combine the patient’s plasma HSP90 a level with histopathological type to predict the prognosis of cancer in future clinical work.