| Purpose1.Urticaria is a common allergic disease.According to the length of the disease,it is divided into acute urticaria(AU)and chronic urticaria(CU).The cause and pathogenesis of chronic urticaria are unknown,and treatment is often difficult.This study analyzed the clinical data of 500 cases of chronic urticaria.The aim is to study the clinical characteristics of chronic urticaria in adults and children,including its causes,laboratory tests,combined diseases and treatments in order to improve the clinician’s understanding of the disease at different ages,thus providing assistance for clinical treatment.2.Chronic urticaria is easy to relapse and often affect the quality of the life of the patients.A dermatology life quality index(DLQI)questionnaire was used to analyze the factors affecting the quality of life of chronic urticaria and the relationship between Helicobacter pylori infection and DLQI score.Objectives and methods1.The clinical data of 500 patients with chronic urticaria who were treated in our dermatology from December 2015 to January 2019 were collected..The data was divided into children group and adults group according to the ages of the patients.Then the gender,age,duration,cause,family history,auxiliary examination,combined disease and treatment between the two groups were analyzed.Statistical analysis was performed on the data using SPSS 22.0 software.The measurement data in normal distribution is represented by the mean plus or minus the standard deviation,and the t-test is used for comparison between the two groups;the measurement data in non-normal distribution is represented by median(25 quartile,75 quartile),between the two groups The comparison was performed using two independent sample rank sum tests;the count data was used as the ratio,and the χ 2 test was used for comparison between the two groups.The test level with α=0.05,P<0.05 was statistically significant.2.The basic information of 150 patients with chronic urticaria who were admitted to the dermatology clinic of our hospital from January 2018 to January 2019 were collected.They filled in the DLQI questionnaire and took the C13 breath test,The DLQI questionnaire consists of 10 questions,including symptoms daily life,sports and entertainment,work and study,interpersonal communication,treatment,et al,in order to analyze the multi-dimensional differences between different genders.The C13 breath test results with ≥4 DOB‰ were determined as the study group,and <4 DOB‰ was determined as the negative control group.The differences between the DLQI scores and other dimensions were compared between the two groups.Statistical analysis was performed on the data using SPSS 22.0 software.The measurement data in normal distribution is represented by the mean plus or minus the standard deviation,and the t-test is used for comparison between the two groups;the measurement data in non-normal distribution is represented by median(25 quartile,75 quartile),between the two groups The comparison uses two independent sample rank sum tests.The correlation between the two variables was analyzed by Spearman correlation.The test level with α=0.05,P<0.05 was statistically significant.Results The first part1 General condition of the patientThere were 500 cases of chronic urticaria,including 72 children,including 47 males and 25 females.The male to female ratio was 1.88:1,aged 1-14 year old,and the average age was 8.36±4.22.There were 428 adults including 194 males and 234 females.The ratio of male to female patients was 1:1.21,aged 15-87 years old,with an average age of 38.54±15.45.The median duration of the children was 4.50(2.00,15.75)months,and the median duration of the adult group was 6.00(3.00,At 33.00)months,there was no significant difference between the two groups(t=-1.879,P>0.05).There were 125 cases(25.0%)out of 500 cases of chronic urticaria with explicit causes,including 20 cases(16.0%)of children,and 105 cases(84.0%)of adults,which were most commonly caused by drugs.There were 38 cases(7.6%)with a family history,including 9 children(23.7%)and 29 adults(76.3%)Whose immediate family members had the most urticaria.2 Laboratory examination2.1 There were 457 cases of hemagglutination test,52 cases(11.4%)were abnormal in the children group and 328 cases(71.8%)were abnormal in the adult group.There were 459 cases of immunoglobulin complement,40 cases(8.7%)in the children group,and 126 cases(27.5%)in the adult group.There were 400 cases of ASO,ESR,CRP and PCT.There were 7 cases(1.8%)in children group that had ASO increase,whereas in adults group the number was 36(9.0%).For ESR,the number of cases with increase for children group and adults groups were 2(0.5%)and 28(7.0%),respectively.There were 28 cases(7.0%)in children group that had CRP increase,whereas in adults group the number was 130(32.5%).For PCT,the number of cases with increase for children group and adults groups were 22(5.5%)and 46(11.5%),respectively.There were 182 cases of thyroid function test,and 5 cases(2.7%)were abnormal in children,and 40 cases(22.0%)were abnormal in adults.A total of 182 thyroid antibodies were detected,4 cases(2.2%)were abnormal in children,and 48 cases(26.4%)were abnormal in adults.There were 154 cases of C13 breath test,4 cases(7.4%)were abnormal in children,and 68 cases(44.2%)were abnormal in adults.Immunoglobulin(Ig)E was detected in 323 cases,27 cases(8.45%)were abnormal in children,and 157 cases(48.6%)were abnormal in adults.Chronic urticaria prothrombin time,prothrombin time activity,international normalized ratio,activated partial thromboplastin time,thrombin time,IgG,IgA and T3 in children and adults were statistically different(P<0.05),while D Dimer,fibrinogen,IgM,C3,C4,T4,TSH,TPOAB,TGAB,TSAB,C13 breath test and serum IgE levels were not significantly different(P>0.05).2.2 There were 323 cases of serum allergens.Among the children’s inhaled allergens,the most common ones were house dust mites/dust mites,penicillium and aspergillus oryzae.The most common allergens of food intake were eggs and milk.Adult inhalation allergens were mostly common with penicillium and aspergillus fumigatus/Aspergillus oryzae,and the allergens from food are mostly common eggs and peanuts.3 ECG and imaging examinationsThere were 371 cases of abdominal color ultrasound,among which 51 cases(13.7%)were for children 5 cases(9.8%)were abnormal,and 320 cases(86.3%)for adults and 181 cases(56.6%)were abnormal.The most common symptom was fatty liver.There were 153 cases of thyroid color ultrasound,among which 16 cases(10.5%)for children,and 7 cases(4.6%)were with abnormal thyroid nodules in grade 2,and there were 137(89.5%)cases for adults with 72(47.1%)abnormalities,with thyroid nodules grade 3 being the most common grade 3.There were 387 cases of ECG,47 cases(12.1%)of children,with 19 abnormal cases(40.4%)of abnormalities,and the central arrhythmia was the most common symptom;340 cases(87.9%)were adults with 81 abnormal cases(23.8%)and ST-T changes was the most common symptom.There were 381 cases of chest CT or DR examination,40 cases(10.5%)of children,including 13 abnormal cases(32.5%)and 341 cases(89.5%)of adults,including 159 cases(46.6%)of abnormal cases,all of which were mostly due to pulmonary inflammation.4 ComorbidityThere were 433 cases with other diseases,For children,there were 6 cases of digestive system diseases in children,5 cases of endocrine system diseases,5 cases of cardiovascular diseases,4 cases of respiratory diseases,3 cases of other skin diseases,and 2 cases of ENT diseases.For adults,there were 140 cases of digestive system diseases in adults,89 cases of endocrine system diseases,63 cases of cardiovascular diseases,40 cases of other skin diseases,21 cases of gynecological diseases,19 cases of respiratory diseases,12 cases of urinary system diseases,12 cases of rheumatic diseases.For example,9 cases of viral hepatitis,2 cases of mental system diseases,and 1 case of orthopedic diseases.5 TreatmentThe treatment of this disease was mainly oral medication.The treatment of children and adults was mainly anti-histamine combined with glucocorticoid in 41 cases and 176 cases,respectively.The remaining treatment options can be combined with immunosuppressants,leukotriene receptor antagonists,antibiotics and proprietary Chinese medicines.The second part1 General situationThere were 150 patients with Cu who participated in the survey,including 64 males and 86 females.The male to female ratio was 1:1.34,aged 16-73 years old,with an average age of 34.97±13.69 years old,male average 33.95±14.86 years old,and female 35.72±12.79 years old.t =-0.781,P > 0.05.The course of disease was 1.5-240 months.The median duration of females was 10.00(4.00,48.00)months,and that of males was 12.00(3.25,36.00)months,Z =-0.421,P>0.05.2 DLQI scoreThe DLQI score was 0 to 30 points,with an average of 8.63 ± 5.29 points,9.14 ± 5.51 points for males and 8.24 ± 5.13 points for females.There was no significant difference in DLQI scores between different genders(P>0.05).Feeling of the symptoms had the greatest impact on CU patients(mean 2.51),followed by daily life(average 2.35).3 Other factors and DLQI scoreGender was negatively correlated with sports and entertainment.Age was negatively correlated with sports and entertainment,work and study,interpersonal communication,and total score.The course of disease was negatively correlated with interpersonal communication.Occupation was negatively correlated with symptom perception,sports and entertainment,marriage and sports entertainment.Negative correlation,and the degree of education is positively correlated with sports and entertainment,work and study,and total scores.4 C13 breath test and DLQI scoreThere was no significant difference between H.Pylori infection and treatment for CU patients(P>0.05).The differences of the other dimensions were statistically significant(P<0.05).Conclusions1 Adults with chronic urticaria are more likely to be in a hypercoagulable state and an autoimmune disorder than children with chronic urticaria;2 Both adult and children with chronic urticaria are susceptible to Helicobacter pylori infection,fatty liver,followed by thyroid nodules and other diseases;3 Feeling of symptoms of chronic urticaria has the greatest impact on patients in our survey for patents’ life quality.4 Chronic urticaria H.Pylori infection-positive patients have a greater impact on quality of life than patients with negative H.Pylori infection. |
PDF Full Text Request