| Objective:To retrospectively analyze the effect of the first-line chemotherapy on the left and right half colon and the effect of the treatment of the compound-like prescription.Methods:In this study,the first line of chemotherapy and syndrome type of the patients with advanced colon cancer during the period from January 2014 to December 2017 in the treatment of advanced colon cancer in the Chinese and Western Medicine Hospital of Hunan Cancer Hospital were retrospectively collected.There were 78 cases of the right(42 cases in the right)and 78 cases of the traditional Chinese medicine loading group(38 cases in the left and 40 in the right).The patient’s name,sex,age,incidence of intestinal cancer,type of pathology,histological grade,site of metastasis,image data before and after treatment(CT or MRI or PET-CT)were recorded,and the total symptom of the syndrome of spleen deficiency,qi stagnation,dampness and blood stasis and the syndrome of the syndrome of spleen deficiency and qi stagnation were recorded before and after treatment.The safety of the drug is assessed by integrating the symptoms of dampness,blood and blood stasis,and recording the blood routine,liver and kidney function and electrocardiogram results of each cycle.All the data were compiled and built into the database using the Excel table,and the statistical analysis was carried out using the SPSS21.0 statistical software package.Results:1.In the total of 160 patients with advanced colon cancer,78 cases of the traditional Chinese medicine loading group and 82 cases of the simple chemotherapy group,the disease control rate(DCR)was 70.5% and 48.8%,respectively.The difference between the two groups was statistically significant(P <0.01).The control rates of the two groups were 84.2% and 62.5%,respectively.There were significantdifferences between the two groups(P <0.05).The control rates of the two groups were 57.5% and 35.7%,respectively.There was a significant difference between the two groups(P <0.05).The control rate of the traditional Chinese medicine loading group was superior to that of the simple chemotherapy group,whether the total or the left or the right colon.2.In the chemotherapy group,there were 40 cases of left colon cancer and 42 cases of right colon cancer.The disease control rate was 62.5% and 35.7%,respectively.there was significant difference between left colon and right colon(P <0.05).In 78 cases of traditional Chinese medicine loading group,there were 38 cases of left colon cancer and 40 cases of right colon cancer.The disease control rate was84.2% and 57.5%,respectively.there was significant difference between left colon and right colon(P < 0.05).The results showed that the disease control rate of left colon cancer was better than that of right colon cancer.3.There were 82 cases in chemotherapy group and 40 cases in left colon cancer group,including 21 cases of liver metastasis,10 cases of peritoneal metastasis and 9cases of others.The constituent ratios were 52.5%,25% and 22.5%,respectively.There were 42 cases of right colon cancer,including 12 cases of liver metastasis,20 cases of peritoneal metastasis and 10 cases of other colon cancer.The constituent ratio was 28.6%,47.6% and 23.8%,respectively.This study shows that the proportion of liver metastasis of left colon cancer is high,and that of right colon cancer is high,which is consistent with the domestic and foreign reports.In left colon cancer,the control rates of liver metastasis,peritoneal metastasis and other diseases after chemotherapy were 71.4%,50% and 66.7%,respectively,and those of right colon cancer were 66.7%,45% and 60%,respectively.Studies at home and abroad have confirmed that peritoneal metastasis may be a factor affecting the difference between left and right colon cancer.The results of this study show that the disease control rate of patients with liver metastasis after chemotherapy is better than that of peritoneal metastasis,which is consistent with the domestic and foreign reports.4.Compared with the traditional Chinese medicine loading group and the simple chemotherapy group,the integral decline of the traditional Chinese medicine loading group was lower,and the difference between the two groups was statistically significant(P <0.01).In the left-left colon cancer,compared with the combination of spleen-deficiency and qi-stagnation and damp-blood-stasis syndrome,the combination of the traditional Chinese medicine loading group and the simple chemotherapy group is less than that before the treatment,the integral decline of the traditional Chinese medicine loading group is more obvious,and the difference between the two groups of symptoms is significant(P <0.01);In the case of the right half colon cancer,the integration of the traditional Chinese medicine loading group and the simple chemotherapy group was reduced,and the integral decline of the traditional Chinese medicine loading group was more obvious,and the symptom score of the two groups was statistically significant(P <0.01).It is indicated that the symptom score of the traditional Chinese medicine loading group is lower than that of the simple chemotherapy group,whether the total or the left half colon or the right half colon cancer patient is integrated.After the treatment,the symptoms of the left and right colon cancer in the left and right colon cancer patients decreased significantly,and the scores of left and right colon cancer were statistically significant(P <0.05).In the treatment of left and right colon cancer,the integral decline of the left and right colon cancer patients was lower,and the difference of integration between left and right colon cancer was statistically significant(P <0.01).It is shown that the left-left colon cancer is more obvious than the right-half colon cancer regardless of the patients with simple chemotherapy or traditional Chinese medicine loading group.5.The scores of single syndrome in left and right colon cancer patients in traditional Chinese medicine loading group were significantly lower than those in right colon cancer group(P < 0.01),and the scores of left colon cancer syndrome were significantly lower than those in right colon cancer group(P < 0.01),and the scores of left colon cancer syndrome were lower than those of right colon cancergroup before treatment(P < 0.01),and there was significant difference between left and right colon cancer patients(P < 0.01).Among the symptoms of qi stagnation,the syndrome score of right colon cancer was lower than that of left colon cancer,and there was significant difference between left and right colon syndrome(P < 0.01).In the symptoms of dampness toxin or blood stasis,the scores of left and right colon cancer syndrome were the same,but there was no significant difference between left and right colon syndrome scores(P > 0.05).It is suggested that the symptoms of qi stagnation in left colon cancer are obvious,mainly empirical,and the symptoms of spleen deficiency in right colon cancer are obvious,mainly deficiency syndrome.It is shown that the different emphasis of each single type of compound syndrome is an important factor affecting the curative effect of traditional Chinese medicine loading therapy,and this study can provide some inspiration for the treatment of left and right colon cancer patients with accurate syndrome differentiation of traditional Chinese medicine to improve the curative effect of right colon cancer.6.The two groups of bone marrow suppression,the digestive tract reaction and the liver and kidney damage of the traditional Chinese medicine loading group and the pure chemotherapy group,There was no significant difference in adverse reactions such as neurotoxicity(P> 0.05).Conclusion:1.The disease control rate and syndrome score of traditional Chinese medicine loading group were better than those of simple chemotherapy group,no matter the total colon or left colon or right colon.2.The disease control rate and TCM syndrome score of left colon cancer were better than those of right colon cancer in both traditional Chinese medicine loading group and chemotherapy group.3.Studies at home and abroad have confirmed that peritoneal metastasis may be a factor affecting the curative effect of left and right colon cancer.The results of this study showed that the proportion of liver metastasis in left and right colon cancer was higher than that in left and right colon cancer.The disease control rate ofpatients with liver metastasis after chemotherapy was better than that of peritoneal metastasis,which was consistent with the domestic and foreign reports.4.In the compound syndrome type,the symptoms of qi stagnation in left colon cancer were more obvious,indicating that the symptoms of spleen deficiency in right colon cancer were more obvious,indicating that deficiency was the main symptom.The results show that the different emphasis of each single type of syndrome is an important factor affecting the curative effect of loading treatment with traditional Chinese medicine.This study can provide some inspiration for patients with left and right colon cancer to improve the curative effect of right colon cancer with accurate syndrome differentiation of traditional Chinese medicine.5.The adverse reactions of the two groups were mild,safe and tolerant. |
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