Correlation Between Parathroid Hormone Levels And Renal Anemia In Patients With Stage 5 Chronic Kidney Disease

Objectives:To analyze the correlation between different levels of parathyroid hormone(PTH)and renal anemia in patients with stage 5 chronic kidney disease(CKD).Methods:189 patients with non-dialysis stage 5 CKD diagnosed at the First Hospital of Jilin University from January 2017 to December 2017 were selected.The patients were divided into three groups according to different levels of PTH: the first group: PTH≤150pg/ml(n=26);the second group: PTH: 150~600 pg/ml(n=149);the third group: PTH: PTH≥600 pg/ml(n=14).The differences of anemia indicators between the three groups were compared and analyzed for their relationship with PTH levels.Results:1.From January 2017 to December 2017,189 patients with nondialysis stage 5 CKD were diagnosed in our hospital,of which 186 had renal anemia,the incidence of renal anemia was 98.4%,and anemia was mainly moderate anemia,accounted for 59.8%.2.There were no significant differences in gender,age and blood pressure between the three groups(P<0.05).3.The blood calcium and blood phosphorus levels of the three groups was compared.There was no significant difference in blood calcium between the three groups(P>0.05).The blood phosphorus levels in the second group and the third group were higher than that in the first group(P <0.05).4.The renal function damage of the three groups was compared.The serum creatinine(Scr)of the second group and the third group was significantly higher than that of the first group(P<0.01),and the Scr of the third group was higher than that of the second group(P<0.05).The blood urea nitrogen(BUN)of the second group and the third group was higher than that of the first group(P<0.05);the estimated glomerular filtration rate(eGFR)of the second group and the third group was significantly lower than that of the first group(P<0.01),and the eGFR of the third group was lower than that of the second group(P<0.05).5.The anemia indicators of the three groups were compared.The hemoglobin(Hb)and hematocrit(Hct)of the first group and the second group were significantly higher than those of the third group(P<0.01),and the Hb and Hct of the second group were significantly higher than that of the third group(P<0.01).6.Correlation analysis results: PTH was positively correlated with serum phosphorus,Scr and BUN(r=0.219,0.404,0.332,P<0.01),and PTH was negatively correlated with eGFR,Hb and Hct(r=-0.399,-0.465,-0.426,P < 0.01).Conclusions:1.Renal anemia is common in patients with stage 5 CKD.The incidence of renal anemia is 98.4%,and anemia is mainly moderate anemia,account for 59.8%.2.PTH is positively correlated with blood phosphorus,that is,the higher the blood phosphorus,the higher the PTH.3.PTH is positively correlated with Scr and BUN.PTH is negatively correlated with eGFR,that is,the heavier the kidney damage,the higher the PTH.4.PTH is negatively correlated with Hb and Hct,that is,the heavier the renal anemia,the higher the PTH.