| ObjectiveThrough study clinical effect of tongyuan Acupuncture combined with clomiphene citrate(CC)on patients with ovulatory disorder infertility,the ovarian follicle and endometrial situation was monitoring by ultrasonic,and furthermore,analyze the ovarian response and the receptivity of endometrium and the pregnancy outcomes.We can see that,tongyuan Acupuncture combined with CC is an effective and safe treatment plan for those patients,which fully carry the advantages of treating methods in ovulatory disorder infertility female.MethodsIn this study,treated in the First Affiliated Hospital of Guangzhou University of Chinese Medicine from June,2017 to December,2018,following the principles and methods of DME,a prospective randomized controlled clinical study was conducted.70 patients with ovulatory disorder infertility were recruited.Those patients were randomly divided into control group(35 cases)and treatment group(35 cases)by method.The patients in the control group were treated with oral administration of CC(50 mg)for 5 days from the 5th day of menstruation;besides the treatment of control group,patients in the treatment group were treated with tongyuan acupuncture.The group A acupoints was mainly consisted of acupoints of the conception vessel,the three yin meridians and front-mu acupoints in abdomen;the group B acupoints was mainly consisted of acupoints of the governor vessel and back-shu acupoints.Two groups of the acupoints were selected alternately,combined with the si-guan points(Taichong(LR 3)、Hegu(LI 4))and five-shu points.The needles were inserted by flying needling method,and retained in human bodies for 30 min,combined with electric acupuncture.Acupuncture treatment was applied once every other day.All patients were treated for 3 months,and treatments stopped if pregnancy occurred.The periodic outcome,maximum diameter of ovarian follicle,HCG days of ovarian follicular development,endometrial thickness and type,pregnancy rate,early abortion rate were compared between two groups.Suspicious events and adverse reactions occurred during the treatment were recorded,and a 3-month follow-up was conducted.Results1.In terms of baseline indicators,the comparison of two groups on age,pregnancy preparation time,pregnancy times,adverse pregnancy times,and the levels of sex hormones such as FSH,LH,LH/FSH,and T,types of ovulatory disorder infertility show that the difference was not statistically significant(P>0.05),so we can conclude that the two groups were comparable with each other.2.To compare the periodic outcome,in the treatment group,the cycle ovulation rate was 70.3%and the cycle LUFS rate was 6.8%and the cycle cancellation rate was 23.0%while in the control group was 53.9%,14.5%,31.6%respectively.The statistically difference of cycle ovulation rate was significant between two groups(P<0.05)while the cycle LUFS rate and cycle cancellation rate were not(P>0.05).3.Ovarian response was compared between two groups.The maximum diameter of ovarian follicle in the treatment group was bigger than that in the control group,and HCG days of ovarian follicular development in the treatment group were longer that those in the control group,with statistically differences(P<0.05).While there was no significant difference in the single ovarian follicle development rate between the two groups(P>0.05).4.Comparison on endometrial receptivity in two groups.The treatment group endometrial thickness and type is superior than those in the control group,which has statistically differences(P<0.05).What’s more,the distribution of endometrial types was also has statistically difference between the two groups(P<0.05).5.Compared with the control group,the total pregnancy rate and the third cycle pregnancy rate in the treatment group were higher than those in the control group,with statistically differences(P<0.05).Meanwhile,compared with the control group,the first cycle pregnancy rate and second cycle pregnancy rate in the treatment group showed no statistically differences(P>0.05).6.In terms of safety,there was no statistically significant difference between the two groups in the risk periodic rate and the incidence of ovarian hyperstimulation(P>0.05).No adverse events of acupuncture or drug occurred in the treatment group,and only 1 case of mild ovarian hyperstimulation occurred in the control group.7.During the follow-up,1 case of early abortion occurred in the experimental group and 2 cases in the control group,which has not statistically difference(P>0.05).The safety indexes of the subjects in both groups were normal.Of the 9 subjects in the treatment group,8 recovered to spontaneous ovulation,and 6 were pregnant.Among the 18 subjects in the control group,10 recovered to spontaneous ovulation,and 6 of them were pregnant.There was no statistically significant difference in the recovery rate of spontaneous ovulation and pregnancy rate during the follow-up period(P>0.05).ConclusionAccording to the analysis of the results,tongyuan Acupuncture can effectively improve the ovarian follicle quality and endometrial receptivity in patients with ovulatory disorder infertility,who was in ovarian induction period with clomiphene citrate,as well as improving the pregnancy rate.Therefore,tongyuan Acupuncture can be used as a safe and effective treating.method to cooperate with modern assisted reproductive technology,which is worthy to be further investigated in the future. |
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