| Obj ectiveTo observe the therapeutic effect of Zuoguiy in on stable angina pectoris of coronary heart disease(heart-kidney-yin deficiency type)and its influence on serum SOD and MD content,and to preliminarily evaluate the effectiveness of Zuoguiy in on stable angina pectoris of coronary heart disease(heart-kidney-yin deficiency type).It is preliminarily confirmed that Zuoguiy in Addition and subtraction Decoction can elevate serum SOD in patients with stable angina pectoris of coronary heart disease(heart-kidney-yin deficiency type).The serum MDA level was decreased and its antioxidant effect was exerted,so as to play a role in the treatment of coronary heart disease.The obj ective basis of the therapeutic effect of the drug was obtained,which provided more clinical and theoretical basis for the treatment of stable angina pectoris(heart-kidney Yin deficiency type)with traditional Chinese medicineMethods60 patients with stable angina pectoris of heart and kidney yin deficiency type were randomly divided into control group(30 cases)and treatment group(30 cases)from April 20 18 to November 20 18 in the Four Cardiovascular Diseases Outpatient Department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine.The treatment group was treated with integrated traditional Chinese and Western medicine,while the control group was treated with conventional western medicine for 4 weeks.After the treatment,we observed the effect of angina pectoris,the change of TCM syndrome integral,the effect of TCM symptoms,the change of nitroglycerin dosage,the change of Seattle Angina Scale,and the change of serum SOD and MDA content.Results1 TCM syndrome score:There was no significant difference in TCM syndrome score between the treatment group and the control group(Z=-1.02 5,P=0.3 0 5).After 4 weeks of corres?ponding treatment,the scores of TCM syndromes in the two groups changed significantly.The scores of TCM syndromes in the two groups decreased significantly compared with those before treatment.However,the scores of TCM syndromes in the treatment group decreased more than those in the control group after regular treatment of integrated traditional Chinese and Western medicine,and the difference between the two groups was statistically significant(P<0.05).2 TCM symptom score,nitroglycerin usage and TCM syndromes curative effect:Through the comparison of the treatment before and after,the treatment group has higher effective rate than the control group in TCM syndromes integral,nitroglycerin usage and TCM syndromes curative effect,the difference is significant(P<0.01),indicating that the treatment group has better therapeutic effect than the control group(P<0.01).3 Seattle Angina Scale efficacy analysis,the treatment group and control group after treatment scale data have improved,but the treatment group scale data are better than the control group(P<0.05),so there is statistical significance.4 Serum SOD and MD A content:After treatment,the serum SOD content in the treatment group and the control group both increased and MDA content decreased,with statistical significance(P<0.01),indicating that the treatment group and the control group had significant changes in serum SOD and MDA content after treatment compared with before treatment,and the treatment effect of the treatment group was better than that of the control group.Conclusion1 Zuogui Yin Jiajianjian Decoction can improve the change of TCM syndrome integral and the curative effect of TCM syndrome in patients with stable angina pectoris of coronary heart disease(heart-kidney Yin deficiency type);the data of Seattle Angina Scale is improved,the quality of life of patients is improved,and the use of nitroglycerin is reduced,suggesting that the application of Zuogui Decoction is effective2 Zuoguiyin Decoction can increase serum SOD and decrease serum MDA in patients with stable angina pectoris(deficiency of heart and kidney yin),which plays an antioxidant role in the treatment of CHD3 There were no adverse reactions in both groups before and after treatment,suggesting that this prescription is safe to use. |
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