Analysis Of The Correlation Between Bone Metabolic Markers And Levels Of Glucose And Lipid Metabolism In Type 2 Diabetes Mellitus

Objectives 1 To study the correlation between osteocalcin,a bone formation marker,and glycolipid metabolism in patients of type 2 diabetes mellitus.2 Study the correlation between carboxyl terminal peptide of collagen type ?,a bone resorption marker,and glycolipid metabolism in patients of type 2 diabetes mellitus.Methods A retrospective analysis was made of 261 patients with type 2 diabetes who were hospitalized in the Department of Endocrinology of the Affiliated Hospital of North China University of Technology(the diagnosis was in accordance with WHO guidelines in1999).The basic data such as height,weight and course of diabetes were measured.The levels of bone metabolic markers,including glycolipid metabolism,osteocalcin and collagen type ? carboxyl telopeptide,were determined.The levels of bone metabolic markers were divided into four groups by quartile method.In four different levels,the differences of glucose and lipid metabolic markers,age,course of disease and body mass index between different levels of bone metabolic markers were compared by single factor analysis of variance.The differences of sex composition were compared by chi-square test.The effects of bone metabolic markers on glucose and lipid metabolism were analyzed by correlation and multiple stepwise linear regression.Results In 261 patients with type 2 diabetes mellitus,osteocalcin,a bone formation marker,was divided into four levels by quartile method.The levels of osteocalcin in OC1group(9.01-40.23ng/L),OC2 group(40.58-46.50ng/L),OC3 group(46.53-56.07ng/L)and OC4 group(56.75-98.00ng/L).The results showed that the levels of HbAlc,FB in patients with type 2 diabetes mellitus were different.G,fasting C-peptide,120-minute c-peptide,TC,LDL-C and Lp(a)had statistical differences(P<0.05).With the increase of osteocalcin,fasting C-peptide and 120-minute C-peptide gradually increased,while HbAlc,FBG,TC,LDL-C and Lp(a)gradually decreased,the change of fasting C-peptide was the most obvious.Multivariate stepwise linear regression analysis showed that when the level of osteocalcin increased,HbA1 c,TC,LDL-C decreased,and fasting C-peptide increased.The carboxyl terminal peptide of collagen I was divided into four levels by quartile method.The carboxyl terminal peptide level of collagen I in CTX1 group was 4.30-28.36 nmol/L,that of collagen I in CTX2 group was 28.49-37.31 nmol/L,that of collagen I in CTX3 group was 37.51-48.00 nmol/L,and that of collagen I in CTX4 group was 48.06-99.78nmol/L.The results of variance analysis showed that there were significant differences in HbAlc,FBG,fasting C-peptide,120 minutes c-peptide,TC and LDL-C among different CTX levels(P<0.05).Multivariate stepwise linear regression analysis showed that when the level of type ? collagen carboxyl terminal peptide increased,HbA1 c,LDL-C increased and fasting C-peptide decreased,the change of HbA1 c is the most obvious.Conclusions 1 The levels of osteocalcin were correlated with HbA1 c,TC,LDL-C and fasting C-peptide in patients with type 2 diabetes mellitus.When the levels of osteocalcin increased,HbA1 c,TC,LDL-C decreased and fasting C-peptide increased,with the increase of osteocalcin level,the change of fasting C-peptide level was the most obvious.2 In type 2diabetes mellitus patients,the level of carboxyl terminal peptide of collagen type ? was correlated with HbA1 c,LDL-C and fasting C-peptide.When the level of carboxyl terminal peptide of collagen type ? increased,HbA1 c,LDL-C increased and fasting C-peptide decreased,with the increase of carboxyl terminal peptide level of collagen ?,the change of HbA1 c level was most obvious.Figs 0;Table 17,References 163.