| Objective:To compare and analyze the characteristics of TCM syndrome elements in different levels of glucose and lipid metabolism in type 2 diabetic patients, we used 320 cases of diabetic patients with the objective value of glycosylated hemoglobin, triglyceride, low density lipoprotein, high density lipoprotein cholesterol and cholesterol as the basis for grouping, and also we compared the differences in basic information, laboratory index and TCM syndrome elements to find the correlation of TCM syndrome elements and laboratory index when they are in different glucose and lipid levels. Provide reference for TCM diagnosis of and treatment of syndrome differentiation of type 2 diabetes.Method:Collecting patients from Dongzhimen Hospital of Beijing University of traditional Chinese medicine, Dongfang Hospital of Beijing University of traditional Chinese medicine, the Third Affiliated Hospital of Beijing University of traditional Chinese medicine, Guang’anmen Hospital Affiliated to China Academy of Chinese Medical Sciences, Wangjing Hospital of China Academy of Chinese Medical Sciences, Xiyuan Hospital of China Academy of Chinese Medical Sciences, General Hospital of PLA, Beijing University First Hospital, Beijing University People’s Hospital, China Japan Friendship Hospital, Beijing Traditional Chinese medicine and Western medicine combined with the hospital, General Hospital of Beijing Military Area Command, Navy General Hospital, Huairou District Hospital of traditional Chinese medicine, Beijing University of traditional Chinese medicine Dongzhimen Hospital District (East) diagnosed with type 2 diabetes from 2013.3 to 2015.12, filling the case report form, including general information and clinical data.Statistical analysis of 320 patients with case data by using SPSS21.0 software package. Describe the general information of the patients, the results of laboratory tests, and other conditions of the disease= Count data using chi square test and test of normality and homogeneity of variance of measurement data, if normal and the variance of the 2 sets of independent samples t test, recording the x±s and P value, and non parametric test for non normality. Compared with glycated hemoglobin, triglycerides, LDL cholesterol, HDL cholesterol, and cholesterol in type 2 diabetic patients and analysis the characteristics of TCM syndrome elements based on different value of glucose and lipid metabolism.Result:1. Analysis of basic information, laboratory indexes and TCM syndrome elements in 320 cases:The inclusion of the patient’s age at most 61-70, mainly overweight, male WHR with more than 0.9, women with the largest range of 0.8-0.9. High blood pressure and hyperlipidemia is more combined with T2DM, and more family history of is hypertension and diabetesIn terms of laboratory index:glycosylated hemoglobin (7.3 (2.1)), cholesterol (4.80± 0.97) exceeded the control target value. Low density lipoprotein (0.97 (2.66)), high density lipoprotein (0.42 (1.11))is nearly to the control target value, Triglyceride (1.55 (1.12)) in the range of control target value.In terms of distribution of syndrome elements:deficiency of Yin(71.25%), Qi (67.50%), kidney Qi (57.81%) frequency of the majority, while damp heat syndrome (39.69%)is more than others.In the correlation of all the TCM syndrome elements and laboratory indexes,Qi deficiency and Yin deficiency are positively correalted with FPG,the positive correlations are cwith FPG,blood stasis is positively correlated with TG,kidney yang deficiency and kidney Qi deficiency are positively correlated with FPG(P<0.05).2.According to the control target value, we compared the basic information, the laboratory index and the TCM syndrome elements.In terms of basic information, the drinking history of HbAlc elevated group are more than HbAlc normal group (P<0.05);SBP, BMI, hyperlipidemia history, smoking history, drinking history, family history of diabetes of high TG are higher than that of normal TG group (P< 0.05), while the ages are lower than normal TG group; SBP and are of low HDL group, are lower than normal group (P< 0.05), smoking history, drinking history, BMI, WHR are higher than that of high density lipoprotein in normal group (P< 0.05);SBP and DBP of high LDL group are higher than that of low density lipoprotein in normal group (P<0.05); Family history of diabetes and DBP cholestrol of TC group are higher than normal group (P<0.05), and smoking histroy of that is lower than the normal cholesterol group (P<0.05).In terms of laboratory indexes, high HbAlc group are higher than normal group, TG higher group in HbAlc, FPG, CHO, LDL higher than normal TG group and HDL lower group and low density cholesterol elevated in the group of CHO, TG, HDL, LDL/HDL and TC/ HDL higher than LDL normal group and HDL lower group in HbAlc, FPG, TG higher than normal control group, TG high group TG, HDL, LDL, LDL/HDL and TC/HDL higher than normal TC group.In terms of the TCM syndrome elements and laboratory indexes, when the body is with high blood sugar, yin deficiency,blood deficiency,damp heat syndrome are positively correlated with FPG(P<0.05), damp heat syndrome is positively correlated with HbAlc(p<0.05),blood stasis syndrome is positively correlated with LDL/HDL(P<0.05).In the body organs deficiency syndrome,spleen deficiency is positively correlated with lipid metabolism(P<0.05);Liver-blood deficiency is positively correlated with LDL/HDL(P<0.05) when the blood sugar is under control.When the TG is not in control, the Qi stasis is positively correlated with HDL(P<0.05);spleen Qi deficiency and spleen Yang deficiency are negatively correlated with HbAlc(P<0.05).When TG is under control,Yin deficiency is positively correlated with FPG,TC/HDL,LDL/HDL(P<0.05).When the LDL is not in control,Qi deficiency is positively correlated with TG,blood deficiency,yin deficiency and hamp heat syndrome are positively correlated with FPG(P<0.05),blood stasis syndrome is positively correlated with HbAlc(P<0.05),heat syndrome is negatively correlated with TG(P<0.05).When HDL is not in control,there is no observed data of elements and laboratory indexes is with statistical sigificance.When HDL is under control,Qi deficiency is positively correlated with TG(P<0.05),blood stasis is positively correlated with HDL(P<0.05),kidney Qi deficiency,kidney yang deficiency are positively correlated with TG and FPG(P<0.05).When TC Is not in control,Qi deficiency is positively correlated with TG(P<0.05),heart blood deficiency is correlated with TC(P<0.05);When TC is under control,qi deficiency,yin deficiency are correlated with FPG and LDL(P<0.05),blood stasis syndrom is correlated with LDL(P<0.05),kideny yang deficiency is correlated with FPG and LDL(P<0.05).Conclusion:1.The main syndrom element of type 2 diabetes is deficiency syndrome(yin deficiency and kidney Qi deficiency), standard excess syndrome is damp heat syndrome.2. With poor control of blood glucose and LDL, blood deficiency, especially liver blood deficiency, yin deficiency syndrome are related with the degree of blood glucose control; With bad control of LDL and TC, Qi deficiency syndrome and TG control are related.3. When the blood sugar control is poor, the liver blood deficiency and FPG is positive correlation; the blood sugar control is good, the liver blood deficiency and LDL/HDL positive correlation. When LDL control is good, blood stasis and TG are positively correlated; When LDL control is poor, blood stasis and HbAlc are positively correlated. When TC control is good, Qi deficiency and FPG, LDL positive correlation; When TC control is bad, Qi deficiency and TG positive correlation4. From the progress of the group and non progression group comparison. It is found that the liver yin deficiency syndrome for the progression to diabetes in high-risk syndrome, with diabetes were followed for up to 12 months in group and non progress group of blood deficiency syndrome, liver yin deficiency and kidney yang deficiency, liver yin deficiency,kidney qi deficiency syndrome of the difference has statistical significance. |
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