| Objective: To investigate the correlation between mild cognitive impairment(MCI)and serum uric acid(UA)and homocysteine(Hcy)in patients with cerebral small vessel disease by detecting the levels of serum UA,Hcy and lipids in patients with cerebral small vessel disease and control group,analyzing whether these serological indexes have statistical differences among the above groups.To provide some new theoretical basises for clinic,namely,risk factors that may cause MCI in patients with cerebral small vessel disease,so as to further carry out early diagnosis and treatment for these patients.Methods: In this study,100 patients with cerebral small vessel disease hospitalized in the Department of Neurology of Shanxian Central Hospital of Shandong Province from January 2018 to January 2019 were selected as research subjects.The cognitive function of each patient was measured by the Montreal Cognitive Assessment Scale(MoCA)and independence was measured by the Activity of Daily Living(ADL)scale.The above cases were divided into non-MCI group and MCI group according to their level of cognitive function.Meanwhile,in order to enhance the persuasion,40 subjects who received health check-ups were enrolled as control group in the same period.3 ml of blood sample(fasting)was taken from every patient in the morning after hospitalization,anticoagulated with heparin,and the levels of serum Hcy,lipids and UA were determined by fully automatic biochemical analyzer(ABC Co.,Ltd.,model: AU 5831)using detection kit(enzyme method)and uric acid determination kit(uricase method),respectively.The data were processed with Excel and analyzed with SPSS 19.0 software,to explore the correlation between their levels and MoCA scores.Results: A total of 100 patients with cerebral small vessel disease were selected in this study.According to their cognitive level,they were divided into non-MCI group(50 cases)and MCI group(50 cases).The average age of non-MCI group was 67.75±4.12 y,with 25 males and 25 females.The average age of MCI group was 68.95±6.21 y,with 27 males and 23 females.The average age of the control group was 63.88±5.6 y,with 22 males and 18 females.Compared with the control group,the levels of serum UA and Hcy both in MCI group and non-MCI group were higher,and the difference was statistically significant(p < 0.05).The levels of serum UA and Hcy in MCI group were higher than those in non-MCI group,and the difference was statistically significant as well(p < 0.05).UA and Hcy values in MCI group were negatively correlated with MoCA total score,attention and computational power,visual space and executive power,abstract power and other sub-items.MCI in patients with cerebral small vessel disease has no correlation with sex,age,body mass index,education level,smoking,drinking,hypertension,diabetes,coronary heart disease and other factors,as well as levels of serum total cholesterol,triglyceride,low density lipoprotein and high density lipoprotein.Conclusion: This study shows that the increase of serum Hcy level in patients with cerebral small vessel disease is closely related to the occurrence of cognitive impairment.Patient with lower level of Hcy tends to have higher cognitive ability score,indicating less cognitive impairment.Meanwhile,it suggests that the increased level of serum UA is closely related to the occurrence of cognitive impairment in patients with cerebral small vessel disease.Serological indexes including Hcy and UA can improve the early diagnosis efficiency of cerebral small vessel disease with cognitive dysfunction.It can provide new theoretical basis and methods for the early treatment of clinical cerebral small vessel diseases with cognitive dysfunction. |
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