Study On The Relationship Between Serum Uric Acid Level And Ca,P,iPTH In Patients With Peritoneal Dialysis

Objective:To investigate the relationship between serum uric acid level and Ca,P and iPTH in patients with single-center maintenance peritoneal dialysis.Methods:136 patients who underwent peritoneal dialysis in our department from January2014 to August 2018 and were followed up regularly for at least 12 months were selected.The subjects were divided into hyperuricemia group(uric acid ≥ 420umol/L)and normal blood uric acid group(uric acid <420umol/L)according to blood uric acid level.The basic conditions of the patients were gender,age and primary disease.The height and height were measured using uniform instruments and standards.Body weight,and calculated body mass index(BMI),using a unified automatic biochemical analyzer to detect blood biochemical indicators of patients with peritoneal dialysis at 12 months,including hemoglobin(Hb),prealbumin(PA),serum albumin(ALB),transfer iron Protein(TRF),blood triglyceride(TG),cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL),serum creatinine(Scr),urea nitrogen(BUN),Blood uric acid(SUA),calcium(Ca),phosphorus(P),magnesium(Mg),alkaline phosphatase(ALP),whole parathyroid hormone(iPTH),and calculated glomerular filtration rate(eGFR).Chi-square test and t-test were used to compare clinical indexes between the two groups.Differences,Pearson correlation analysis and logistic regression analysis further analyzed the factors affecting the increase of SUA and their correlation with each index.Results:1.Comparison of clinical data between high uric acid group and normal uric acid group(1)A total of 136 patients were enrolled,including 78(57.35%)males and 58(42.65%)females with an average age of(52.13±12.56)years.60 cases(44.12%)of chronic glomerulonephritis in the primary disease,followed by 44 cases(32.35%)of diabetic nephropathy and 19 cases(13.97%)of hypertensive renal damage,and 13 cases(9.56%)of other causes.(2)A total of 56 patients(41.18%)in the hyperuricemia group,including 30 males and 26 females,with an average age of 51.25±11.04 years,an average SUA level of466.70±39.81umol/L;a total of 80 patients with normal blood uric acid For example,there were 48 males and 32 females with an average age of 52.74±12.25 years and an average SUA level of 318.28±59.61umol/L.Compared with the normal serum uric acid group,SBP,ALB,Scr,TC,P,iPTH were higher in the hyperuricemia group than in the normal uric acid group,and the HDL level was lower than the normal uric acid group.The difference was statistically significant(P<0.05);There was no significant difference in gender,age,primary disease,BMI,Ca,ALP and eGFR between the two groups(P>0.05).2.Correlation analysis between SUA and various clinical indicatorsWith uric acid levels as independent variables,Pearson correlation analysis showed that SUA and SBP(r=0.473,P<0.001),ALB(r=0.220,P=0.010),Scr(r=0.203,P=0.018),TC(r)=0.199,P=0.020),P(r=0.488,P<0.001),iPTH(r=0.508,P<0.001)showed a positive correlation.3.Multiple linear regression analysis of risk factors for elevated SUAUsing uric acid as the dependent variable and adjusting the confounding factors,multiple linear regression analysis showed that SBP(β=0.737,P=0.029),TC(β=13.073,P=0.034),Scr(β=0.045,P=0.023),P(β = 48.972,P = 0.001),iPTH(β = 0.213,P = 0.001)is a risk factor for elevated blood uric acid.Conclusion:Patients with peritoneal dialysis are often complicated with hyperuricemia.Serum uric acid is closely related to P and iPTH,and P and iPTH are risk factors for the increase of serum uric acid in patients with peritoneal dialysis,the specific mechanism needs to be further studied.