Effect Of Acupuncture On The Number Of Retrieved Oocytes And The Rate Of High-grade Embryo In Patients With Poor Ovarian Response To IVF Mild-stimulation

Objective:In this study,acupuncture treatment was used to treat patients with IVF poor ovarian response mild-stimulation,and the effect of the treatment on the number of retrieved oocytes,high-grade embryo rate was observed.Methods:In this study,a randomized controlled trial of 66 poor ovarian response subjects was randomly assigned to the treatment group（acupuncture+mild-stimulation regimen）or the control group（mild-stimulation regimen）.Acupuncture treatment was performed before the oocyte was taken from February to March 3（excluding the menstrual period）,three times a week,30 minutes each time,the number of acupunctures was 20.80±1.59 times/person,and the control group only used the mild-stimulation program.Observed the number of retrieved oocytes,the rate of high-grade embryo,the rate of fertilization,the level on HCG day（E₂,P）and the serum levels of essential hormones（FSH,LH,P,E₂）and anxiety between the groups before and after treatment.Differences in self-rating scale（SAS）scores and depression self-assessment（SDS）scores.Results:1.Baseline analysis results:There was no significant difference between the baseline data and statistical analysis（P>0.05）,which was comparable;2.Main outcomes after treatment:the number of retrieved oocytes in the treatment group was higher than that in the control group,and the difference was statistically significant（P<0.05）;the rate of high-grade embryo in the treatment group was higher than the control group,and the difference was statistically significant（P<0.05）.3.Other relevant indicators after treatment:（1）The fertilization rate of the treatment group was higher than that of the control group,and the difference was statistically significant（P<0.05）;（2）The serum levels of FSH and E₂ in the treatment group were higher than those in the control group and E₂,and the difference was statistically significant（P<0.05）;There was no statistically significant difference between serum basal hormone P and LH levels in the treatment group and serum basal hormone P level and LH level（P>0.05）.Serum basic hormones in the group:FSH and E₂ levels in the treatment group were significantly lower than those after treatment FSH and E₂,and the difference was statistically significant（P<0.05）.（3）The level of blood hormone E₂ in the treatment group was higher than that in the control group,and the difference was statistically significant（P<0.05）;the treatment group HCG injection There was no significant difference in the level of hematopoietic hormone P from the blood glucose P in the control group（P>0.05）.（4）The treatment group’s self-rating anxiety scale（SAS）score and depression self-assessment（SDS）score were lower than the control self-rating scale（SAS）score,depression self-rating（SDS）score,and the difference was statistically significant（P<0.05）.Conclusions:1.Acupuncture can increase the number of retrieved oocytes and the rate of high-grade embryo in patients with indications of poor ovarian response with IVF mild-stimulation.2.Acupuncture can improve the fertilization rate of patients with indications of poor ovarian response with IVF mild-stimulation,and improve their sex hormone levels（FSH,E₂,E₂ before oocytes retrieval）,anxiety and depression.