Efficacy And Safety Of Romosozumab In The Treatment Of Osteoporosis Of Postmenopausal Women:A Meta-Analysis

Objective: To evaluate the efficacy and safety of Romosozumab in the treatment of osteoporosis of postmenopausal women.Methods: Databases including PubMed,Embase,Cochrane Library,OVID and Web of Science were searched from October 2018 to collect randomized controlled trials(RCTs)and quasi-randomized controlled trials(q-RCTs)about Romosozumab for the postmenopausal women with osteoporosis.The Review Manager 5.3 software was used for Meta-analysis.Results: Six RCTs were included with 12127 cases in all.A significant difference were found in bone mineral density(BMD)and risk of fractures,but no statiscally significant differences in any adverse event.Conclusions: For postmenopausal women with osteoporosis,Romosozumab could improve the bone mineral density,reduce the risk of fractures,and it doesn’t increase the rate of any adverse event,clinical priority.