| ObjectiveTo evaluate the effect of high flow nasal cannula oxygen therapy on preventing postoperative pulmonary complications with meta-analysis.MethodsPubMed in literature database of American National Library,Holland Medical Abstract Embase and the Cochrane Library were systematically searched from their inception to December 31,2018.And the updated search was conducted on February 28,2019.The references from relevant articles were searched.All the collected randomized controlled trials followed the inclusion and exclusion criteria.The experimental group was treated with high flow nasal cannula oxygen therapy while the control group was treated with conventional oxygen therapy.The outcome indicators included tracheal reintubation rate,pneumonia incidence,mortality,length of intensive care unit stay and hospital length of stay.Two researchers evaluated the quality of literature,and extracted data respectively.All data was analyzed by RevMan5.3software.Funnel plot was used to analyze the publication bias.ResultsFinally,after Meta analyses,a total of 7 randomized controlled trials were enrolled,involving 1063 patients and 531 of them in the experimental group and 532 in the control group.Meta-analysis showed that compared with the control group,the tracheal reintubation rate(OR=0.30,95%CI=0.10 ~0.85,P=0.02)and hospital length of stay(MD=-0.26,95%CI=-0.49~-0.02,P=0.03)was lower in the experimental group.But there was no significant difference in pneumonia incidence,mortality and length of intensive care unit stay between experimental group and control group.It was suggested by the funnel plot analysis that there was low publication bias.ConclusionCompared with conventional oxygen therapy,high flow nasal cannula oxygen therapy could reduce the reintubation rate and hospital length of stay in postoperative patients,although there were no statistical significant differences in pneumonia incidence,mortality and length of intensive care unit stay between the two groups. |
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