| Object: To analyze the interaction between quality of life(QOL),anxiety and depression,serum vitamin D levels and disease activity of patients with mild-moderate ulcerative colitis(UC),we detect QOL score,anxiety and depression score,serum vitamin D levels in mild-moderate UC patients before and after treatment..Methods: The criteria of diagnosis,disease severity and treatment principles meet with The Consensus on Diagnosis and Treatment of Inflammatory Bowel Disease issued 2012.We collected 30 patients with mild-moderate UC diagnosed at the First Affiliated Hospital of the Medical College,Shihezi University.The mental status of these patients was evaluated by Hospital Self-Rating Anxiety and Depression Scale(HADs),these patients’ life quality was evaluated by quality of life universal scale(SF-36)and Inflammatory Bowel Disease Quality of Life Questionnaire(IBDQ),the levels of serum vitamin D were detected by electrochemiluminescence,all these date or score was collected at before treatment and three months after treatment.And we detected the levels of serum vitamin D in healthy people without intestinal diseases diagnosed by colonoscopy.Results: A total of 30 patients with mild-moderate UC were collected,including 21 mild and 9 moderate,all of which were relieved after treatment.at the same time,25 healthy controls were collected.The main results were as follows:(1)QOL in patients with mild-moderate UC after treatment was higher than that before treatment: the total score of IBDQ in patients with mild-moderate UC(t=8.98,P<0.01)and the score of each dimension after treatment were significantly higher than those before treatment;the total score of SF-36 in mild-moderate UC patients(t=6.43,P<0.01)was significantly higher than that before treatment.Except for physiological function,the other dimensions were significantly higher than before treatment,the difference was statistically significant.(2)The anxiety and depression of patients with mild to moderate UC improved significantly after treatment: the overall anxiety(t=3.861,P<0.01)and depression(t=5.817,P<0.01)of mild-moderate UC patients were improved after treatment;the constituent ratios of anxiety patients was(46.67% vs 16.67%,P<0.05)and depression patients was(36.67% vs 10%,P<0.05).The levels of anxiety(P<0.05)and depression(P<0.01)in patients with moderate UC were higher than those in patients with mild UC before treatment.(3)The total score of IBDQ(t=3.267,P<0.01)and the scores of all dimensions in mild-moderate UC patients with anxiety and depression before treatment were lower than those in UC patients without anxiety and depression.(4)Before treatment,the anxiety and depression scores of mild-moderate UC patients were negatively correlated with the total score of IBDQ(r=-0.622,P<0.01)and each dimension,and the difference was statistically significant.(5)In the evaluation of QOL by SF-36,the total score of SF-36(t=6.03,P<0.01),somatic pain(t=3.515,P<0.01)and general health status(t=5.116,P<0.01),energy(t=4.469,P<0.01),emotional function(t=3.811,P<0.01),mental health(t=4.284,P<0.01)were significantly improved in mild-moderate UC patients without anxiety and depression before treatment.Except for physiological function(t=1.953,P > 0.05)and social function(t=1.646,P> 0.05)in mild-moderate UC patients with anxiety and depression before treatment,the total score of SF-36 and the other dimensions were significant differences.The scores of physiological function(t=2.305,P<0.05),general health status(t=2.799,P<0.01)and energy(t=2.237,P<0.05)in mild to moderate UC patients with anxiety and depression before treatment were lower than those without anxiety and depression.;(7)Vitamin D levels in patients with mild-moderate UC were lower than those in healthy subjects(23.59 ± 16.78,34.98 ± 15.09vs45.35 ± 15.55 ng/mL,P<0.01,P<0.05).The level of serum25OHD3 in patients with mild-moderate UC after treatment was significantly higher than that beforetreatment(23.59 ± 16.78 vs 34.98 ± 15.09 ng/mL,P< 0.01).(8)there was no significant difference in25OHD3 level between mild and moderate UC patients(27.07±18.58 vs 16.44±9.28 ng/mL,P > 0.05).Conclusion: 1.Anxiety,depression and quality of life are closely related to disease activity,effective UC treatment is the main strategy to improve QOL score and relieve anxiety and depression status.2.For mild-moderate UC patients,the basic therapy is treating the origin disease: UC,and we should follow-up the psychological status of these patients.If patients are continuous with anxiety and depression after treatment,psychological intervention should be carried out immediately.3.Compared with the healthy people,the level of serum vitamin D in mild-moderate UC patients is lower.The mild-moderate UC patients’ serum vitamin D level increases as the clinical symptoms relief,but also lower than which in healthy people.Considering the physiological function of vitamin D,we speculate that low levels of vitamin D may be associated with the occurrence of UC,but irrelevant with the severity of UC. |
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