Observation On The Curative Effect Of Traditional Chinese Medicine Of Tongfujiangzhuo In Patients With IBS-C And Its Effect On CRH,ACTH,CORT

Objective: By observing and Analyzing the improvement of Clinical symptoms,quality of life and improvement of curative effect and the changes of endocrine index CRH,ACTH and CORT in patients with IBS-C after taking Traditional Chinese Medicine of Tongfujiangzhuo,the mechanism and clinical effect of IBS-C were explored.This paper introduces the theory of turbid toxin into the clinical treatment of IBS-C,expands the therapeutic field of turbid toxin theory,and enriches the theoretical system of TCM in treating functional bowel disease.Methods: Seventy patients with constipation irritable bowel syndrome were randomly divided into two groups by random digital table,including thirty-five subjects in the treatment group.Give Traditional Chinese Medicine of Tongfujiangzhuo,one dose per day,take warm water in the morning and evening;Thirty-five subjects in the control group were given cisapride tablets orally,5 mg,three times a day,given warm boiled water(During the experiment,2 cases in the treatment group were lost follow-up,3 cases in the control group,of which 1 case lost the follow-up,2 cases took other drugs in the middle of the experiment.).Subjects in both groups received treatment for4 weeks.The follow-up was carried out for 3 month after the end of the treatment course,and the clinical symptoms,the curative effect and the quality of life of the patient were compared before and after the treatment,and ELISA method was used to detect the content of endocrine index CRH,ACTH and CORT in the serum of the patients.Final unified progressive number According to statistics and analysis,t-test was used to measure data,chi-square-test was used to count data,rank and test are adopted for the grade data,and SPSS21.0 software was used to analyze the data.P < 0.05 was considered statistically significant between the two groups,and P > 0.05 was considered not statistically significant between the two groups.Results: Traditional Chinese Medicine of Tongfujiangzhuo can improve the uncomfortable symptoms of IBS-C patients and has long-term therapeutic effect.Traditional Chinese Medicine of Tongfujiangzhuo can improve abdominal pain,defecation difficulty,dry mouth does not want to drink,eat less or early satiety,er,reverse qi.The curative effect of anal scorching was better than that of cisapride tablets.;Quality of Life score:Traditional Chinese Medicine of Tongfujiangzhuo can improve the quality of life of patients and have long-term therapeutic effect,the effects of improving anxiety(Q1),behavioral disorder(Q2),health anxiety(Q4),food picking(Q5),social reaction(Q6),sexual behavior(Q7)and interpersonal relationship(Q8)were better than those of cisapride tablets;Evaluation of efficacy:the effective rate after treatment was 87.88% in the treatment group and 62.50% in the control group,the effective rate in the treatment group was significantly higher than that in the control group;Determination of serum CRH,ACTH,CORT:Traditional Chinese Medicine of Tongfujiangzhuo can reduce the content of serum CRH,ACTH,CORT in patients with IBS-C,the decrease of serum CRH,ACTH,CORT content in the treatment group was significantly better than that in the control group.Conclusions: Traditional Chinese Medicine of Tongfujiangzhuo can effectively improve the symptoms of patients,can significantly improve the quality of life of patients,with a better clinical efficacy;Traditional Chinese Medicine of Tongfujiangzhuo can reduce the content of serum CRH,ACTH,CORT in patients with IBS-C and can effectively regulate the disturbance of HPA axis function.