| Objective:To observe the clinical effect of Yu's Gout External Application Granule in the treatment of(Gouty joint)acute stage of gouty arthritis with dampness-heat accumulation.Material and methods:According to inclusion and exclusion criteria,60 cases of acute gouty arthritis with damp-heat accumulation were selected.Two groups were randomly divided into two groups: the treatment group was treated by external application of Yu's Gout External Application Granule and diclofenac sodium sustained release tablet orally,and the control group was treated by oral administration of diclofenac sodium alone.The indexes before and after treatment(TCM quantitative score,TCM curative effect score,joint pain score,joint swelling degree,leukocyte,neutrophil,C-reactive protein,erythrocyte sedimentation rate,hematuria acid value,whole blood viscosity)were compared between the two groups.Observe the therapeutic effect.Results :1.The clinical efficacy evaluation of traditional Chinese medicine:the cure rate of the treatment group was 10.0%,the obvious effective rate was 53.3%,the effective rate was 30.0%,the ineffective rate was 6.7%,the total effective rate was 93.3%,the cure rate of the control group was 3.33%,and the obvious effective rate was 46.67%.The effective rateis 40.0%,the inefficiency is 10.0%,and the total effective rate is90%.There was significant difference between the treatment group and the control group(P < 0.01),and the treatment group was superior to the control group.2.Comparison of TCM symptom scores between the treatment group and the control group before and after treatment,the scores of TCM symptoms in the treatment group and the control group were obtained by paired sample t-test: P < 0.01,with significant statistical significance.The results showed that the symptoms of traditional Chinese medicine in the treatment group and the control group were improved obviously after the treatment.After treatment,the scores of TCM symptoms in the treatment group and the control group were obtained by independent sample t test: P = 0.048< 0.05,indicating that there was a significant difference in the distribution of TCM symptoms between the two groups,and that the treatment group was superior to the control group in the distribution of TCM symptoms.3.The VAS score and joint swelling degree score of the two groups were observed.There was significant statistical difference between the treatment group and the control group before and after treatment(P < 001),indicating that after treatment,the VAS score of the treatment group and the control group was significantly higher than that of the control group(P < 0 01).The degree of joint swelling was significantly improved compared with that before treatment.There was significant difference between the treatment group and the control group after treatment(P <0.01),which indicated that the treatment group had better effect in relieving joint pain and reducing joint swelling than that in the control group.4.Comparison of leukocyte(white blood cell,WBC,neutrophil count(Neutrophil count,NEUT),C reactive protein(C reactive Protein,CRP)anderythrocyte sedimentation rate(Erythrocyte Sedimentation Rate,ESR)data showed that: after treatment,the two groups were lower than those before treatment.The difference was statistically significant(P < 0 05),indicating that after treatment,both the treatment group and the control group could reduce the WBC,NEUT,CRP,ESR;.There was significant difference between the two groups after treatment(P < 0.05).The treatment group was superior to the control group in reducing inflammatory index.5.The peripheral diameter of the joint in the two groups was significantly improved after treatment(P < 0.01),and in the third day after treatment,the peripheral diameter of the joint in the treatment group was significantly better than that in the control group(P < 0.05).There was no significant difference in the improvement of joint circumference between the two groups on the seventh day after treatment(P > 0.05).6.Comparison of serum uric acid: before and after treatment,there was no statistical significance(P > 0.05),but there was no significant difference between groups after treatment(P > 0.05).7.Hemorheology:Intragroup comparison:1.Whole blood reduction viscosity of 200(1/ S),full blood reduction viscosity of 50(1/ S)(Whole Blood Retive Viscose 50,RT50),full blood reduction viscosity of 30(1/ S)(Whole Blood Retive Viscosiness 30,RT30),full blood reduction viscosity of 5(1/ S)(Whole Blood Retive Viscosiness5,HII),full blood reduction viscosity 1(1/ S)(Whole Blood Retive Viscosiness 1,RT1),Plasma viscosity(XIND),total blood-reducing viscosity: High Shea,HGQ,Carson Viscose,KS,Total blood-reduced viscosity: Low Blood Retive Viscose: Low Shea,HDQ,Red Cell Rigidity Index(HGX),The K value of erythrocyte sedimentation equation(ESR,KValue,XCK)was lower than that before treatment(P <0.01),and the difference of erythrocyte pressure product(Hematrit,HCT)was higher than that before treatment(P <0.01),and the whole blood high-shear relative index(WHC)was higher than that before treatment(P <0.01).In GQXD,the relative index(DQXD)of the whole blood was lower than that of the pre-treatment,and the P <0.05 was obtained by the paired t-test,and the difference was of statistical significance.2.The RT200,RT50,RT30,HGQ,KS,HGX,XCK of the control group before and after treatment was lower than that of the pre-treatment,and the HCT of the control group was higher than that of the pre-treatment.The paired sample t-test showed that the difference was significant(P < 0.01).The RT1,XIND,HDQ,GQXD,DQXD was lower than that before treatment.By paired sample t test,the difference was statistically significant(P < 0.05).3Red blood cell aggregation coefficient(VA)(Erythrocyte Aggregation Coefficient,HIIXS)decreased and erythrocyte deformability index(TK)(Red Cell Deformation Index,HBX)increased before and after treatment in the treatment group.After paired sample t test,the results showed that there was no significant difference between the two groups(P > 0.05).There was no significant difference between the two groups.The HII,HIIXS of control group before and after treatment was lower than that of pre-treatment,and the HBX of control group was higher than that of pre-treatment.The results of paired sample t test showed that there was no significant difference(P > 0.05).Comparison between groups:1.After treatment,the whole blood reductive viscosity was 200(1 /S),the whole blood reductive viscosity was 50(1 / S),the whole blood reductive viscosity was 30(1 / S),the whole blood reductive viscosity was 5(1 / S).Whole blood reductive viscosity 1(1 / S),plasma viscosity,hematocrit,whole blood reductive viscosity: high shear,Casson viscosity,whole blood reductive viscosity: low shear,erythrocyte rigidity index,erythrocyte sedimentation equation K value,by independent sample t test,The difference was statistically significant(P < 0.05),indicating that the hemorheology of the treatment group was significantly improved than that of the control group.2.RBC aggregation coefficient(VA),erythrocyte deformability index(TK),whole blood high shear relative index(TK),)and whole blood low shear relative index(LSI)of the two groups were not significantly different after treatment(P > 0.05).Conclusion:1.The clinical effect of Yu's gout external application granule and diclofenac sodium sustained-release tablet was better than that of oral diclofenac sodium sustained-release tablet alone in the treatment of acute stage of gouty arthritis with damp-heat accumulation.2.Yu's gout external application granules plus diclofenac sodium sustained-release tablets oral efficacy score is higher than simple diclofenac sodium sustained-release tablets oral,suggesting that external application of traditional Chinese medicine can effectively improve the symptoms and signs of patients.3.The effect of external application of Yu's gout granule and diclofenac sodium sustained release tablet on relieving pain swelling was better than that of diclofenac sodium sustained release tablet alone.4.Yu's external application of gout granules and diclofenac sodium sustained-release tablets were more effective in reducing joint circumference than diclofenac sodium sustained-release tablets alone.5.The effect of external application of Yu's external application of gout granules and diclofenac sodium sustained-release tablets on serum uric acid was not obvious.6.The treatment of acute gouty arthritis by external application ofYu's external application of gout granules and diclofenac sodium sustained release tablets was superior to that of diclofenac sodium sustained-release tablets in improving whole blood viscosity. |
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