| Aims:We expect to have a knowledge of the epidemiology of hepatitis B virus and estimate the effectiveness of HBV vaccine through investigating the seroepidemiology of hepatitis B virus in Dagang District,Tianjin City.Moreover,based on the investigation of the HBV seroepidemiology of puerperae in Dagang District,we try to uncover the potential issues in the control of HBV and put forward some suggestions to improve the prevention of vertical transmission of neonatal HBV.Methods:Patients were selected randomly in Dagang Hospital of Tianjin from August,2017 to July,2018.The puerperae were selected randomly in Dagang Hospital of Tianjin from November,2014 to July,2018.HBsAg,HBsAb,HBeAg,HBeAb,HBcAb were detected by time-resolved fluoroimmunoassay.HBV-DNA were detected by the fluorescence probe method,which is low.Results:According to age,subjects were divided into 8 groups respectively(0-20,21-30,31-40,41-50,51-60,61-70,71-80 and over 81 years old).The total positive rate of HBsAg among all aged population was 3.77%.The HBsAg positive rate among male population was higher than that among female population(4.52%VS3.16%,χ2=6.445,P<0.05).HBsAg positive rate in 0-20 years old group was the lowest(0.49%),followed by the positive rate in over 81 years old group(0.86%)and the highest positive rate was in 41-50 years old group(5.71%).The positive rate of HBsAg showed a trend that the positive rate was higher among middle age subgroup and lower among younger and elder age sub group.The total positive rate of HBsAb was 48.19%.Among them,the highest positive rate lies under 20 years of age,which was 58.74%.The positive rate of HBsAb declined with age.The total positive rate of HBcAb was 44.24%.The male positive rate was 51.29%,which is higher than the female positive rate(51.29%VS38.47%,χ~2=159.523,P<0.05).Among them,the positive rate was the highest in people over 81 years old(62.64%)and was the lowest in people under 20 years old(5.83%).The positive rate of HBcAb rose with age.In addition,we analyzed the data from puerperae in Dagang District.The puerperae were divided into 3 groups respectively(under 25 years old,26-35 years old,and over 36 years old)based on age.The total positive rate of HBsAg among all aged puerperae population was 3.84%and the positive rate of HBsAg rose with age.In contrast,the totalHBsAb positive rate among all aged puerperae population was35.87%and it declined with age.The positive rate of HBsAg showed significant differences among age subgroup as well as the positive rate of HBsAb(χ~2=3472.368,P<0.05;χ~2=3521.175,P<0.05.Moreover,the detection rate of HBV-DNA is only23.31%.Conclusion:Compared with the results of HBsAg epidemiology in 2006,the positive rate of HBsAg significantly declined.However,compared with the HBsAg epidemiology of Tianjin in 2010,HBsAg positive rate in Dagang District is at a high level.There were significant differences in the age groups of the people in Dagang District as well as gender groups.The positive rate of HBsAg is higher among male population than female population and it is the highest in 41-50 years old group.Therefore we should put more attention to these populations and take even more effective measures to control HBV.In addition,compared with the results of HBsAg epidemiology in 2006,the positive rate of HBsAg among puerpera in Dagang Districtsignificantly declined.As the main fertility population,the puerpera aged 26-35 years old should inoculate or re-inoculate hepatitis B vaccine as much as possible.Meanwhile,the HBV-DNA detection rate of HBsAg-positive pregnant women should be improvedin order to take effective measures to prevent mother-to-fetus transmission of HBV. |
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