Effect Of Computer Cognitive Remediation Therapy On Cognitive Function In Female Patients With Remission Schizophrenia

Objective: Most defects cognitive symptoms in patients with schizophrenia,in patients with schizophrenia was secondary memory,immediate memory,ability to execute on the task,the early visual information processing,verbal fluency,logical thinking ability,attention and psychomotor function obstacle,and with positive and negative symptoms,become an independent group of symptoms.This research adopts the cognitive orthodontic treatment system(computer cognitive remediation therapy,CCRT)as the basic therapeutic tool,combined with atypical antipsychotics olanzapine,treating remission women patients with schizophrenia,before and after treatment applied cognitive test battery for schizophrenia,consensus version(MATRICS consensus cognitive MCCB)for the evaluation of patients with diseases about his mental cognitive impairment,To investigate the effect of CCRT treatment on cognitive function in female patients with remission schizophrenia。Methods: A total of 42 female patients with schizophrenia in remission whose age,educational background and course of illness were matched were collected。42 patients were identified as in the remission phase of schizophrenia after a Brief Psychiatric Rating Scale(BPRS)with a total score of <30。Criteria for inclusion:Diagnostic criteria for schizophrenia,in the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition,DMS-5;The patient was 18-60 years old;The course was > for 2 years,All patients were treated with olanzapine and their condition was stable,All subjects were informed of the content of the experiment and contraindications,All subjects agreed to be enrolled and signed the informed consent.。Professional researchers who had been trained and passed the examination were responsible for data collection and scale evaluation。The patients were randomly assigned to the cognitive correction treatment group and the control group by the numerical method。Among them,the cognitive correction treatment group used the computer cognitive correction system as the treatment tool on the basis of drug therapy,while the control group only used drug therapy。The experiment lasted for 12 weeks,MCCB was used to evaluate the cognitive function of patients in the two groups before treatment,6 weeks after treatment and 12 weeks after treatment,and the Positive and Negative Syndrome Scale(PANSS)was used to evaluate the clinical efficacy。Results: 1、 After 6 and 12 weeks of treatment,the differences in MCCB scores of the cognitive correction treatment group in symbol coding 、number sequence、spatial breadth、semantic fluency、continuous operation、verbal memory、visual memory、maze and total score were statistically significant compared with those before treatment(P<0.05);The MCCB scores of the control group were significantly different from those before treatment(P<0.05)。2、After 12 weeks of treatment,there were statistically significant differences in MCCB scores in continuous operation、number sequence、 verbal memory、visual memory、maze and total score between the cognitive correction treatment group and the control group(P<0.05)。3、12 weeks after treatment,the cognitive orthodontic treatment group total PANSS scale(to improve the percentage of scope for:-4%-5%)and negative symptoms,improve the percentage of scope for:-17%-21%)of the difference was statistically significant compared with before treatment,clinical trials in general think PANSS deducted rate > 25% to think clinical symptoms improved,therefore can be thought of as negative symptoms improved in this study,there is no actual clinical significance。Conclusion: 1.CCRT treatment can significantly improve some cognitive functions of female patients with remission schizophreni。2.Atypical antipsychotic drugs can improve some cognitive functions of patients with schizophrenia。3.CCRT treatment did not significantly improve the mental symptoms of female patients with remission schizophrenia.