Comparison Of Effects Of Oxycodone And Sufentanil On Early Circulatory Function About Pneumoperitoneum Of Laparoscopic Cholecystectomy

Objective:To observe the effects of oxycodone and sufentanil on early circulatory function about pneumoperitoneum of laparoscopic cholecystectomy.Methods:Forty patients undergoing laparoscopic cholecystectomy at the First Affiliated Hospital of China Medical University from November 2017 to June 2018,aged 18 to 65 years,falling ASA ? or ? grade,were randomly divided into two groups: oxycodone group(group O)and sufentanil group(group S),20 cases each group.Both groups were given midazolam 0.02mg/kg,etomidate 0.3mg/kg,cis-atracurium 0.2mg/kg for anesthesia induction,Group O and group S were received intravenous injection oxycodone 0.3mg/kg and sufentnnil 0.3?g/kg respectively.Both of groups were targeted controlled infusion of propofol and intravenous infusion of remifentanil for intraoperative maintenance.Mean arterial pressure(MAP)and heart rate(HR)were recorded before anesthesia induction(T0),the moment of inserting laryngeal mask(T1),before pneumoperitoneum(T2),1,3,10,20,30 min after pneumoperitoneum(T3,T4,T5,T6,T7),5 min after deflation(T8).According to the hemodynamic parameters,the remifentanil infusion rate was adjusted after T4,so that the MAP and HR fluctuation amplitude was ±20% of the basal value,and the total usage of remifentanil in group O and group S was compared.VAS scores was used to record incisional pain,visceral pain,and shoulder pain at 2,4,and 24 hour after surgery.The postoperative adverse reactions such as respiratory depression,delayed recovery,and nausea and vomiting were assessed as well.Results:Two groups of patients characteristics and operative data were no significant difference(P >0.05).There were no significant difference in MAP and HR at T0,T1 and T2 betweeen the two groups.Compared with T2,both of the MAP and HR at T3,T4 increased in two groups(P <0.05),but the increase in group O was less than that in group S(P <0.05).Total consumption of remifentanil : group O was less than group S(P < 0.05).The VAS scores of visceral pain and shoulder pain at 2h and 4h were significantly lower in group O than in group S(P <0.05).There was no significant difference between the two groups at 24 h after operation(P >0.05).There was no significant difference in the incidence of postoperative drug-related adverse reactions between the two groups(P >0.05).Conclusion:Oxycodone is better able to maintain hemodynamic stability of early pneumoperitoneum during laparoscopic cholecystectomy,and is superior to sufentanil in relieving abdominal visceral pain without increasing the incidence of adverse reactions.