| Section 1: Correlation between thyroid hormone level and non-alcoholic fatty liver disease in Xi’an,Shaanxi provinceObjective: To investigate the correlation between thyroid function and nonalcoholic fatty liver disease(NAFLD).Methods: Eligible subjects were selected from the population of diabetes epidemic investigation in Shaanxi province from 2012 to 2013.Thyroid function and related metabolic indexes were compared between NAFLD group and control group.Risk factors for NAFLD were determined by logistic regression model.Results: Among the 971 subjects,FT4 level of NAFLD group was higher than that of the control group.NAFLD prevalence increased with FT4 level(P=0.000).FT3 level was positively correlated with WC,BMI,TG,UA,ALT and Cr,and negatively correlated with TC and HDL-C.FT4 level was positively correlated with WC,SBP,TC,TG,LDL-c,UA,FPG,Gr,and negatively correlated with HDL-C.Binary logistic regression analysis showed that the risk of NAFLD in FT4 2nd to 4th quartile(Q2-Q4)was higher than that in FT4 1st quartile(Q2: OR2.04,95%CI: 1.14-3.63 Q3:OR2.74,95%CI: 1.57-4.80;Q4:OR3.41,95%CI: 1.94-6.01).Besides,female,obesity,abnormal glucose metabolism are risk factors of NAFLD.Conclusion: this study suggests that FT4 level is positively correlated with NAFLD risk within the normal range of thyroid function.Section 2: Correlation between thyroid hormone level and metabolic syndrome in Xi’an,Shaanxi provinceObjective: To analyze the correlation between thyroid hormone and metabolic syndrome and its components.Methods: The research object was the population from survey of Shaanxi Province in2012-2013.All subjects underwent height,weight,blood pressure,waist circumference,body fat,electrocardiogram,oral glucose tolerance test,blood lipids,liver function,renal function,thyroid hormone,and questionnaires were filled out.First,according to the thyroid function,the difference in the incidence of MS and related components between the hyperthyroidism group,the hypothyroidism group and the normal group was compared.Then,only the subjects of normal thyroid function were selected,and the differences in metabolic parameters and MS prevalence of each group were compared after quartile grouping according to TSH and FT4.Finally,the logistic regression model was used to analyze the correlation between MS and related components and thyroid hormone levels.Results: A total of 1103 subjects were enrolled,30 in the elevated thyroid function group,28 in the decreased thyroid function group,and 1045 in the normal thyroid function group.There was no significant difference in the prevalence of MS or it’s components between different thyroid function groups.The levels of TC and LDL-C in patients of elevated thyroid function group were lower,and the difference was statistically significant.The prevalence of MS in the overall population was 30.5%,and the prevalence of MS in women was higher than that in men,mainly because of that women had a higher prevalence of abdominal obesity and lower HDL-C.In patients with normal thyroid function,MS patients had higher levels of FT4 and TSH than non-MS patients.The prevalence of high TG in female increased along with the TSH level,and the prevalence of hypertension and high FPG increased along with FT4 level.The prevalence of low HDL-C in males increased along with TSH,and the prevalence of high TG increased along with FT4.After using logistic regression model to correct for sex,age and other confounding factors,FT3 levels in the normal range were positively correlated with MS and abdominal obesity,high TG,and low HDL-C.FT4 levels were positively associated with MS,high TG,hypertension,and high FPG.,and the TSH level was positively correlated with the prevalence of high TG.Conclusion: There is no correlation between thyroid dysfunction and MS in the overall population.In people with normal thyroid function,FT3 and FT4 levels were positively correlated with the prevalence of MS and its various components,and TSH levels were only positively correlated with the prevalence of high TG. |
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