| Objective:The aim of the study was to observe the effect of acupoint application of traditional Chinese medicine and auricular acupressure(cowherb seed)as adjuvant therapy on acute and delayed nausea and vomiting after cisplatin based chemotherapy,and whether there is synergistic effect in the combined application of different acupoint therapies.Meanwhile,the effects of the two therapies on patients’ quality of life and chemotherapy-related concomitant symptoms were discussed,so as to provide basis for clinical application.Methods:132 cisplatin combined chemotherapy patients were divided into 4 groups according to the single-blind randomized controlled method,and the allocation was hidden using envelopes.They are group A(control group),group B(auricular acupressure group),group C(acupoint application group)and group D(auricular acupressure combined acupoint application group).We observed respectively the incidence of chemotherapy-induced nausea and vomiting,adoption of remedial treatment,life quality of patients and chemotherapy-related concomitant symptoms on the three days during chemotherapy and the first,third and fifth day after chemotherapy.Results:Firstly,comparison between the three experimental group and the control group:On the 2nd to 3rd days during chemotherapy and the 3rd day after chemotherapy,the incidence of chemotherapy-related nausea in group B,group C and group D wassignificantly lower than that in group A(P<0.05).On the 1st day after chemotherapy,the group C and group D was significantly lower than that in group A(P<0.05),but the difference between group B and group A was not significant(P>0.05).On the 2nd to 3rd days during chemotherapy and the 1st and 3rd days after chemotherapy,the proportion of moderate or severe nausea in group B,group C and group D was significantly lower than group A(P<0.05).During the 1st day of chemotherapy and the5 th day after chemotherapy,there was no statistical difference in the incidence of chemotherapy-related nausea and the proportion of moderate to severe nausea among the four groups(P>0.05).(2)During the observation period,the incidence of chemotherapy-related vomiting in the three experimental groups was lower than that in group A,but the difference was not statistically significant(P>0.05).On the 2nd to 3rd days during chemotherapy and the 3rd day after chemotherapy,the proportion of moderate to severe chemotherapy-related vomiting in group B,group C and group D was significantly lower than that in group A(P<0.05).However,on the 1st day after chemotherapy,only group D was statistically different from group A(P<0.05).On the1 st day during chemotherapy and the 5th day after chemotherapy,there was no significant difference in the proportion of moderate to severe vomiting among the four groups(P>0.05).(3)On the 2nd to 3rd days during chemotherapy and the 3rd day after chemotherapy,the number of patients receiving remedial treatment in group B,group C and group D was significantly lower than that in group A(P<0.05).On the 1st day after chemotherapy,only group D was statistically different from group A(P<0.05).On the 1st day during chemotherapy,there was no statistical difference among the four groups(P>0.05).On the 5th day after chemotherapy,no patients in the four groups received remedial treatment.(4)The quality of life scores of the three experimental groups were significantly higher than those of group A(P<0.05).The incidence of fatigue and abdominal distension in the three experimental groups was significantly lower than that in group A(P<0.05).The incidence of dizziness in group B and group D was significantly lower than that in the control group(P<0.05),but there was no significant difference between group C and group A(P>0.05).There was no significant difference in the incidence of constipation and diarrhea among four groups(P>0.05).Secondly,Comparison among the three experimental groups:The results of all the observation indicators in group D were better than those in group B and group C,but there was no significant difference among the three groups(P>0.05).Conclusion:(1)Single or combined acupoint application of TCM and auricular acupressure have a good preventive effect on acute and delayed nausea and vomiting after cisplatin based chemotherapy,which can significantly reduce the incidence of chemotherapy-related nausea and the severity of chemotherapy-related nausea and vomiting,and control chemotherapy-related vomiting at a low level in some period of time.(2)Single or combined application of acupoint application of TCM and auricular acupressure can significantly improve the quality of life of patients,and alleviate abdominal distension and fatigue of patients.Auricular acupressure can alleviate the symptom of dizziness.(3)The effect of acupoint application of TCM combined with auricular acupressure on cisplatin chemotherapy-related nausea and vomiting is better than that of the two treatments alone,but there is no obvious synergistic effect. |
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