The Comparison Of The Different Influence On Immunosurveillance Of Hepatocellular Carcinomaprecise By Precise Hepatectomy Combined With TACE And Routine Hepatectomy Combined With TACE

Objective:To compare the influence of immune surveillance in patients with hepatocellular carcinoma after precise hepatectomy combined with TACE and routine hepatectomy combined with TACE.Methods:41 patients with HCC who were admitted to our hospital from June 2016 to December 2018 were randomly divided into precision hepatectomy group(21 cases)and routine hepatectomy group(20 cases).The levels of CD4+,CD8+,CD4+/CD8+,IL-10 and IFN-y in peripheral blood before and after TACE were compared between the two groups.Results:Seven days after operation,CD4+,CD4+/CD8+,IL-10 and IFN-γ in the two groups decreased,but CD4+,CD4+/CD8+and IFN-γ in the precise hepatectomy group decreased less than those in the conventional hepatectomy group(P<0.05),and CD8+in the two groups increased slightly(P>0.05).Fourteen days after operation,and the levels of lymphocyte and immunocytokine were restored to the preoperative level.Seven days after TACE,the levels of CD4+,CD8+,CD4+/CD8+and IFN-γincreased,while the levels of IL-10 decreased,but there was no significant difference between the two groups(P>0.05)Conclusion:Compared with routine hepatectomy,the immune function of patients recovered faster after precise hepatectomy.Postoperative TACE can promote immune surveillance.