Analysis Of Incidence And Related Factors Of Postoperative Intracranial Infection In Patients With Intracranial Tumor

Background: Hospital Infection(Nosocomial Infection,Hospital Infection)is also known as hospital Acquired Infection or nosocomial infection.With the widespread use of antibacterial drugs,bacterial infection resistance,pathogen variation,disease spectrum change,and population aging have led to high infection rates among nosocomial infections.In particular,the hospital infection rates in developing countries are much higher than in developed countries.The most serious infection in nosocomial infections is intracranial infection(ICI).ICI is the common complication of neurosurgery,it is because the reason such as traumatic,operation causes the protection of tissue around human body and blood-brain barrier and defensive function to suffer serious damage,disease-causing microorganism invades nervous system to cause a kind of acute,subacute,chronic expression.Once an infection occurs,it can lead to serious neurological sequelae and systemic complications,aggravating the patient’s condition and causing death in severe cases.ICI has many influencing factors,which can be summarized into three aspects: preoperative infection risk factors,intraoperative infection risk factors and postoperative infection risk factors.Therefore,only the identification of risk factors for ICI will provide a theoretical basis for effective prevention and control of nosocomial infections in the future.Objective: This study investigated and analyzed 268 patients with intracranial tumor craniotomy in a brain surgery department in a hospital in Qiqihar City,so as to understand the occurrence of intracranial infection and related influencing factors,in order to provide evidence for effectively preventing the occurrence of intracranial infection and improving the quality of life of patients.Methods: 268 patients with intracranial tumors admitted to the brain surgery of a top three hospital in Qiqihar City from January 2018 to June 2019 were selected as subjects.In this study,a cross-section method was adopted to collect general demographic data(age,gender,education,etc.),disease history data(patients with diabetes,hypertension,etc.),surgical related factors(number of operations,time,etc.)were collected from qualified patients by trained nurses or doctors in the form of case investigation.All data descriptions and analyses were performed using SPSS 24.0 statistical software.Mean(?X)and standard deviation(SD)were used for measurement data,and frequency and composition ratio(%)were used for statistical description of counting data.Classification data using χ2 test to compare differences in intracranial infection rates among patients with different clinical features.Influencing factors of intracranial infection with statistically significant differences in univariate analysis were included in multivariate logistic regression,and stepwise regression was used to explore independent influencing factors of postoperative intracranial infection.P<0.05 was considered statistically significantResults: 1.Intracerebral infection occurred in 26 of 268 patients who underwent intracranial tumor craniotomy,with an infection rate of approximately 9.7%.2.Univariate analysis showed that patients with diabetes mellitus,operation time > 4 hours,cerebrospinal fluid leakage after surgery and postoperative indwelling extra-ventricular drainage tube were risk factors for ICI(P<0.05),while,gender,age,ethnicity,BMI classification,education level,occupational category,marital status,patients with hypertension,number of operations,and postoperative albumin < 35g/L were not associated with ICI,and the difference was not statistically significant(P>0.05).).3.Logistic regression analysis showed: operation time(P<0.001,OR=6.624,95% CI=2.074~18.806),postoperative indwelling extra-ventricular drainage tube(P<0.001,OR=3.694,95% CI=2.124~14.806)and postoperative cerebrospinal fluid leakage(P=0.032,OR=1.425,95% CI=1.116~1.820)was an independent risk factor for ICI,and the difference was statistically significant.Conclusion: 1.The study found that the ICI rate was 9.7%.2.Patients with diabetes mellitus is risk factors for ICI,but it is not an independent risk factor for infection,which may be combined with other factors to cause ICI.3.Surgery time > 4 hours,postoperative ventricular drainage tube and postoperative cerebrospinal fluid leakage are independent risk factors for ICI.The operation time > 4 hours had the greatest impact on ICI(OR=6.624),followed by postoperative ventricular drainage tube(OR=3.694)and postoperative cerebrospinal fluid leakage(OR=1.425).