Abdominal Aortic Calcification And Its Risk Factors In Patients With Different Types Of Primary Aldosteronism

Objective: To investigate abdominal aortic calcification and its risk factors in patients with different types of primary aldosteronism(PA).Methods: We included 156 PA patients who underwent adrenal venous sampling(AVS),and 156 with essential hypertension(EH)matched by age,sex in the Hypertension Center of The People's Hospital Of Xinjiang Uygur Autonomous Region from January 2017 to December 2017.Of the former,76 were diagnosed as unilateral PA and 80 as bilateral PA.Aortic calcification index(ACI)which showed the severity of AAC was measured by adrenal computed tomography(CT)scan.Results: Compared with EH group,the prevalence of AAC was higher in patients with PA(32.69 vs 19.53%,P=0.036),and a higher ACI showed more severe AAC(4.32 ± 3.61 vs 2.53 ± 2.42%,P = 0.037).In PA subgroup analysis,unilateral PA presented a higher and more severe AAC than bilateral PA(40.79 vs 25.00%,P=0.013;5.12±4.07 vs 3.08±2.34%,P=0.048,respectively).Moreover,plasma aldosterone cancentration and parathyroid hormone(PTH)levels were higher in unilateral PA than bialateral PA(P<0.05).After risk-adjustment,multivariate regression analysis revealed that PAC and PTH were positively associated with AAC in patients with PA(OR 1.209,95%CI 1.087-1.346,P<0.001;OR 1.026,95%CI 1.006-1.047,P =0.011,respectively).Conclusions: Unilateral PA patients exhibited higher prevalence and more severe AAC than patients with bilateral PA,which was associated with high PAC and PTH levels.