| ObjectiveTo observe the clinical efficacy of jinghua weikang capsule combined with bismuth in the treatment of hp-associated gastritis,and to investigate the eradication rate,improvement of clinical symptoms and incidence of adverse reactions in the treatment of hp-associated gastritis by combining traditional Chinese and western medicine.Methodsfrom September 2018 to September 2019,70 patients diagnosed as Hp infection by chronic gastritis through digestive endoscopy and13C-UBT or14C-UBT were collected from the outpatient clinic of li tianwang,director of hubei provincial hospital of traditional Chinese medicine.They were randomly divided into control group and observation group,with 35 patients in each group.The control group was treated with bismuth-containing quadruple therapy:esomeprazolase enteric-coated tablets 20 mg + amoxicillin dispersive tablets 1000 m g + clarithromycin 500 mg + bismuth potassium citrate particles 220mg,twice a day for 14 days;In the observation group,240 mg jinghua weikang capsule was added to the control group twice a day for 14 days.The clinical symptoms(abdominal pain,abdominal distension,poor appetite and belching)were observed and recorded before and after treatment.After 1 month of drug withdrawal after treatment,the13C-UBT or14C-UBT was rechecked,the eradication of Hp was counted,and the occurrence of adverse reactions in the two groups of patients during the treatment was recorded.Results(1)age,gender,drinking history,smoking history,family history of gastric cancer and other basic information of patients in the two groups were statistically analyzed,and the difference was not statistically significant(P>0.05),which was comparable.(2)improvement of symptoms:(1)Improvement of abdominal pain: after treatment,the score of abdominal pain degree and frequency in the observation group decreased significantly compared with the control group,and the difference was statistically significant(*P<0.05);After treatment,the score of abdominal pain degree and frequency in the observation group and control group decreased significantly compared with that before treatment,and the difference was statistically significant(△P<0.05).(2)improvement of abdominal distension: after treatment,abdominal distension degree and frequency score in the observation group decreased significantly compared with the control group,and the difference was statistically significant(*P<0.05).After treatment,the abdominal distension degree and frequency score of the observation group and control group decreased significantly compared with that before treatment,and the difference was statistically significant(△P<0.05).(3)Improvement of tolerance: after treatment,the tolerance degree and frequency score of the observation group decreased significantly compared with the control group,with statistically significant difference(*P<0.05).After treatment,the difference between observation group and control group was significantly lower than that before treatment(△P<0.05).(4)improvement of belching: after treatment,compared with the control group,the degree and frequency of belching in the observation group decreased significantly(*P<0.05).After treatment,the degree and frequency of belching in the observation group and the control group decreased significantly compared with that in the treatment group(△P<0.05).(5)comparison of the total score of each symptom degree: after treatment,the total score of each symptom degree in the observation group decreased significantly compared with the control group,and the difference was statistically significant(*P<0.05).After treatment,the total score of symptoms in the observation group and control group decreased significantly compared with that before treatment,and the difference was statistically significant(△P<0.05).(6)Comparison of total frequency scores of symptoms: after treatment,the total frequency scores of symptoms in the observation group decreased significantly compared with the control group,and the difference was statistically significant(*P<0.05);After treatment,the total score of symptom frequency in the observation group and control group decreased significantly compared with that before treatment,and the difference was statistically significant(△P<0.05).(7)Comparison of total scores of symptoms: after treatment,the total scores of symptoms in the observation group decreased significantly compared with the control group,and the difference was statistically significant(*P<0.05);After treatment,the total scores of all symptoms in the observation group and control group decreased significantly compared with those before treatment,and the difference was statistically significant(△P<0.05).(3)comprehensive efficacy evaluation of each group after treatment:(1)Comprehensive efficacy evaluation after treatment of abdominal pain: the rank-sum test was used to evaluate the comprehensive efficacy of the two groups of patients after treatment,and the difference between the two groups was statistically significant(P<0.05),suggesting that the improvement effect of abdominal pain symptoms in the observation group was better than that in the control group.(2)Comprehensive efficacy evaluation after treatment of abdominal distension: the rank-sum test was used to evaluate the comprehensive efficacy of the two groups of patients after treatment,and the difference between the two groups was statistically significant(P<0.05),suggesting that the improvement effect of abdominal distension symptoms in the observation group was better than that in the control group.(3)comprehensive efficacy evaluation after the treatment of poor tolerance: the rank-sum test was used to evaluate the comprehensive efficacy of the two groups of patients after the treatment,and the difference between the two groups was statistically significant(P<0.05),suggesting that the improvement effect of the observation group was better than that of the control group.(4)Comprehensive efficacy evaluation after belching treatment:the rank-sum test was used to evaluate the comprehensive efficacy of the two groups of patients after treatment,and the difference between the two groups was statistically significant(P<0.05),suggesting that the improvement effect of belching symptoms in the observation group was better than that in the control group.(4)comparison of Hp eradication rates between the two groupsThe eradication rate was 96.9% in the observation group and 76.4%in the control group.After treatment,the eradication rate of the two groups was compared by Pearson’s corrected 2 test,and the difference between the two groups was statistically significant(P<0.05).The results showed that the eradication rate of the observation group was better than that of the control group.(5)adverse reactions occurred in the two groupsThere were 2 cases of adverse reactions in the observation group,and the incidence of adverse reactions was about 6.0%.There were3 cases of adverse reactions in the control group,and the incidence of adverse reactions was about 8.8%.Pearson’s corrected 2 test was used to compare the occurrence of adverse reactions between the two groups,and there was no significant difference between the two groups(P>0.05).There was no significant difference in the occurrence of adverse reactions between the two groups.ConclusionJing Hua weikang capsule with bismuth agent quadruple therapy can significantly improve the Hp correlation gastritis eradication rate and improve the clinical symptoms,the effect is significantly higher than pure bismuth agent quadruple therapy,but adverse reactions between the raw situation has no obvious difference,combine traditional Chinese and western medicine treatment of Hp correlation gastritis clinical significance,for Hp correlation gastritis patients clinical treatment provides a new thought and method... |
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