An Analysis Of Clinical Value Of Red Blood Cell Distribution Width And Platelet Count In Non-small Cell Lung Cancer

Objective: To investigate the diagnostic value of red blood cell distribution width(RDW),platelet count(PLT)and combination of platelet and red blood cell distribution width(COP-RDW)with non-small cell lung cancer and the relationship between tumor stage,lymph node metastasis,distant metastasis.Methods:From August 2017 to August 2019,the patients with non-small cell lung cancer in Department of Respiratory Medicine and Thoracic surgery of Yijishan Hospital of Wannan Medical College of Wuhu City were selected as the research subjects,After the inclusion criteria and elimination criteria,123 NSCLC patients were finally selected as the research subjects.At the same time,30 cases of health examination subjects were selected as normal group.It’s a retrospective analysis of differences of RDW、PLT、COP-RDW between non-small cell lung cancer and healthy control groups,by drawing ROC curves to test the sensitivity and specificity of the three indicators above.To explore the differences between RDW、PLT、COP-RDW in groups according to the pathological stage,lymph node metastasis,distant metastasis.Results:1.The RDW levels of NSCLC group and normal group were 13.11±1.06、12.62 ± 0.77,P=0.017,the difference was statistically significant.There was no significant statistical difference of PLT level between NSCLC and normal groups.The median of COP-RDW in NSCLC group was 1 while in normal group was 0,P<0.05,the difference has statistical significance.2.Except for pathological type(P < 0.05),there was no significant statisticaldifference of RDW、PLT between age,sex,smoking history,tumor side,tumor location(P < 0.05).COP-RDW were not statistically significant in age,sex,smoking history,pathological type,tumor side,tumor site(P>0.05)3.The RDW level of tumor I stage was lower than that of the II、III、IV stage,which was statistically significant different;the RDW level of the II stage was lower than that of the patients in the IV stage,and the difference was statistically significant.PLT,although gradually increasing with the degree of staging,there was no statistical difference between tumor periods(P>0.05).The COP-RDW level of patients in the tumor I stage was only statistically significant with that of patients in the IV stage(P=0.010),and when we compare the level in II,III,IV stages,it turns P > 0.05 all,which shows no statistical significance.The RDW,PLT,COP-RDW levels in early patients(stage I,II)were all statistically significant compared with those in advanced patients(stage I,II)(P<0.05).4.RDW、PLT levels of patients with N0 stage non-small cell lung cancer were not statistically significant compared with N1,N2(P > 0.05),which when compared with N3,P<0.05,the difference was statistically significant;the difference of RDW、PLT levels between N1,N2,N3 stage was not statistically significant.The COP-RDW level of N0 stage was not statistically significant compared with N1,N2 stage,when compared with N3,P < 0.05 the difference has statistical significance.There was no significant difference of COP-RDW level between N1 stage and N2 stage,P>0.05,when compared with N3,the difference was statistically significant,P < 0.05.The difference of COP-RDW level between N2 and N3 stage was not statistically significant,P>0.05.5.The RDW 、 COP-RDW levels were statistically significant in distant metastasis groups and without distant metastasisgroups(P < 0.05).There was no statistical difference between the PLT level of the distant metastasis group and nodistant metastasis groups(P>0.05).6.There was relativity between RDW in tumor stage,lymph node metastasis and distant metastasis(r=0.317,0.234,0.190,P<0.05).There was also correlation in PLT between tumor stage and lymph node metastasis(r=0.218,0.250,P < 0.05),however PLT level in distant metastasis was not statistically significant(r=0.170,P>0.05).There was relativity between COP-RDW in tumor stage,lymph node metastasis and distant metastasis(r=0.304,0.263,0.224,P<0.05).7.The sensitivity of RDW in distinguishing NSCLC and normal group was73.30%,specificity was 53.70%,AUC was 0.635;the sensitivity of PLT for screening NSCLC was 86.70%,specificity was 36.60%,and AUC was 0.616;sensitivity of COP-RDW was 63.30%,specificity was 72.30%,and specificity was 0.678,AUC was0.678.Conclusion: 1.There were some reference significance when we use RDW、COP-RDW to distinguish non-small cell lung cancer from normal group,while the COP-RDW specificity is higher.2.There were some relativity between RDW、PLT、COP-RDW with tumor stage and lymph node metastasis degree of non-small cell lung cancer.3.RDW、COP-RDW is correlated with distant metastasis.