| BackgroundThe majority of lung cancer originated from the bronchial mucosal epithelium,so also known as bronchial lung cancer.With the acceleration of industrialization,the incidence of lung cancer has shown a significantly increasing trend.As far as we know,lung cancer is the most common malignant tumor in men.With the passage of time,the ratio of lung cancer in women is also more and more higher.The early symptoms of lung cancer are often not typical,and a large proportion of patients have been found to have distant metastasis,so it is very important for the early detection of lung cancer.Positron emission tomography/computer tomography(PET/CT)is more sensitive and comprehensive for the diagnosis of lung cancer,which provides the basis for clinical functional imaging.ObjectiveThe purpose of this study is to explore the gender and age distribution characteristics of patients with peripheral solid lung adenocarcinoma and lung squamous cell carcinoma,and to compare and analyze the18F-Fluorodeoxyglucose(18F-FDG)PET/CT performances of peripheral solid lung adenocarcinoma and lung squamous cell carcinoma,so as to provide reliable clinical and functional imaging data for clinicians in the diagnosis of peripheral solid lung cancer.MethodsFrom April 2017 to July 2019,Ninety-eight patients with peripheral solid lung cancer examined in the nuclear medicine discipline of the First Affiliated Hospital of Xinxiang Medical College were divided into squamous cell carcinoma group and adenocarcinoma group according to the final diagnostic criteria of surgical resection or percutaneous lungbiopsy with clear pathological results.All the subjects were examined by PET/CT and chest thin slice CT.The patients’ gender,age,lesion location,the largest diameter(mm)and maximum standardized uptake were recorded in detail Value,SUVmax)and various CT signs(with or without lobulation sign,burr sign,vascular bundle sign,pleural depression sign,bronchial truncation sign,vacuole sign,bronchial inflation sign,cavity,necrosis,emphysema,bone metastasis).Results1.The proportion of male and female patients with peripheral solid lung adenocarcinoma and lung squamous cell carcinoma was statistically significant(P<0.01).The proportion of female patients with lung adenocarcinoma(37/69,53.6%)was slightly higher than that of male patients,and the proportion of male patients with lung squamous cell carcinoma(24/29,82.8%)was significantly higher than that of female patients.2.There was no significant difference in the proportion of male and female patients with peripheral solid lung cancer,lung adenocarcinoma and lung squamous cell carcinoma in different age groups(P>0.05),with the peak age of onset concentrated in 51-60 years old(29/98,29.6%;9/29,31.0%;20/69,29.0%)and 61-70 years old(38/98,38.8%;11/29,37.9%;27/69,39.1%).3.The age of onset of peripheral solid lung squamous cell carcinoma was all over 40 years old(29/29、100%),and only one female case of lung adenocarcinoma was under 40 years old(1/69、1.45%).The age of onset of lung squamous cell carcinoma(65.21±8.68)was significantly higher than that of lung adenocarcinoma(59.55±9.58)(P<0.01).4.There was no statistically significant difference between the two groups in gender,age,and lesion site SUVmax in peripheral solid lung squamous cell carcinoma and lung adenocarcinoma(P>0.05).There was no significant difference between two groups with different lesion sites(P>0.05).5.There were significant differences between peripheral solid adenocarcinoma and squamous cell carcinoma in the presence or absence of lobulation sign,burr sign,pleural depression sign,vacuole sign,bronchial inflation sign,cavity,necrosis,emphysema,bone metastasis(P<0.05).6.There was no significant difference between peripheral solid lung adenocarcinoma and lung squamous cell carcinoma in the presence of vascular cluster sign and bronchial truncation sign(P>0.05).7.SUVmax of peripheral solid lung squamous cell carcinoma(12.70±5.01)was significantly higher than that of lung adenocarcinoma(9.13±5.32)(P<0.01),the maximum diameter of the tumor(mm)(46.34±21.24)was significantly greater than that of lung adenocarcinoma(32.59±18.33)(P<0.01),and the SUVmax(13.32±5.31)of the tumor group(the maximum diameter of the tumor>30mm)was significantly greater than that of the nodule group(the maximum diameter of the tumor<30mm)(6.79±3.07)(P<0.05).8.There was no significant difference in tumor maximum diameter(mm)and SUVmax between the group with and without bone metastases of peripheral solid lung cancer,the group with bone metastases of peripheral solid lung squamous carcinoma and the group with bone metastases of lung adenocarcinoma(P>0.05).9.There is a significant negative correlation between SUVmax and gender(r=-0.690,P<0.01);There is a significant positive correlation between SUVmax and the maximum tumor diameter(r=0.652,P<0.01).There is a significant negative correlation between SUVmax and pathological types(r=-0.379,P<0.01).There is no correlation between SUVmax and age,site(P>0.05).ConclusionPET/CT can provide anatomical and metabolic information at the same time,which is of certain value in the differential diagnosis of peripheral solid lung adenocarcinoma and lung squamous cell carcinoma. |
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