Clinical Observation Of Shen Ling Bai Zhu San In Treating Chronic Obstructive Pulmonary Disease In Stable Phase(Lung-Spleen Qi Deficiency Syndrome)

Objective:By observing the patient’s TCM syndrome score,6-minute walking distance test（6MWD）,quality of life assessment（CAT）,lung function indicators（FVC,FEV₁/FVC,FEV₁%）,peripheral blood T lymphocyte subsets CD4⁺,CD8⁺,CD4⁺/CD8⁺and inflammatory factors IL-17 and IL-23 indicators,objectively evaluate the clinical efficacy of Shen Ling Bai zhu San in the treatment of COPD patients with stable stage（Lung-Spleen Qi Deficiency Syndrome）.Methods:Random number table method was used to divide 96 patients with stable COPD（Lung-Spleen Qi Deficiency Syndrome）into the control group and treatment group,48 cases in each group.The control group was treated with Western medicine Tiotropium bromide inhalation powder aerosol.The treatment group was combined with Shen Ling Bai zhu San on the basis of Western medicine.Both groups of patients were treated for 3 months.After 3months of regular treatment,observe the TCM syndrome score,6-minute walking distance test（6MWD）,quality of life assessment（CAT）,lung function indexes FVC,FEV₁/FVC,FEV₁%,peripheral blood T Changes of lymphocyte subsets CD4⁺,CD8⁺,CD4⁺/CD8⁺and inflammatory factors IL-17and IL-23,To explore the therapeutic effect of Shen Ling Bai zhu San on COPD patients in stable stage（Lung-Spleen Qi Deficiency Syndrome）.Results:1.After 3 months of regular treatment,the total effective rate of the control group was 80.85%,and the total effective rate of the treatment group was88.64%.2.After treatment,The symptoms of cough,sputum,wheezing,shortness of breath and spontaneous sweating in the control group were improved compared with before treatment（P<0.05）.In the treatment group,the symptoms of cough,sputum,wheezing,shortness of breath,spontaneous sweating,colds,anorexia,abdominal distension,lumbago,and nocturia were more improved than before treatment（P<0.05）.3.After treatment,the CAT scores of the two groups decreased compared with before treatment（P<0.05）,and the CAT score of the treatment group was more than that of the control group（P<0.05）.4.After treatment,the 6MWD of the two groups was longer than before treatment（P<0.05）,The 6MWD of the treatment group was longer than that of the control group（P<0.05）.5.After treatment,FVC,FEV₁/FVC and FEV₁%in both groups were improved compared with before treatment（P<0.05）,The improvement of FVC,FEV₁/FVC and FEV₁%lung function indexes in the treatment group was better than that in the control group（P<0.05）.6.After treatment,the peripheral blood T lymphocyte subsets CD4⁺、CD8⁺、CD4⁺/CD8⁺of the control group had no significant difference compared with before treatment（P>0.05）,and the CD4⁺and CD4⁺/CD8⁺indexes of the treatment group increased compared with before treatment（P<0.05）,CD8⁺immunological index decreased（P<0.05）.7.After treatment,the IL-17 and IL-23 of the two groups decreased compared with before treatment（P<0.05）,and the IL-17 and IL-23 indexes of the treatment group decreased more than the control group（P<0.05）.Conclusion:In the theory of"deficiency is to mend its mother","to cultivate soil to produce gold","nourishing the spleen and stomach,benefiting the lung Qi",Shen Ling Bai zhu San combined with conventional western medicine in the treatment of COPD stable period（lung-spleen qi deficiency syndrome）can help patients with clinical efficiency,relieve clinical symptoms,reduce CAT score,extend 6MWD,improve patients’FVC,FEV₁/FVC,FEV₁%,improve patients’immune function,reduce inflammatory factors IL-17,IL-23levels,and improve patients’quality of life,No obvious adverse reactions occurred during the clinical research.