| Objective: Through the clinical observation of Qingrejiedu Fuzheng Decoction in the treatment of pulmonary sepsis with heat phlegm and stasis syndrome,to explore the clinical efficacy of Qingrejiedu Fuzheng Decoction in the treatment of pulmonary sepsis with phlegm-heat and blood stasis syndrome and its effect on inflammatory mediators,and to find a new therapeutic target and therapeutic drug for pulmonary sepsis with integrated traditional Chinese and Western medicine,and lay a foundation for the development of nosocomial preparations.Methods: From February 2018 to December 2019,72 patients with heat phlegm and stasis syndrome of pulmonary sepsis who met the diagnostic criteria were randomly selected from the department of emergency and ICU inpatients of Yunnan Provincial Hospital of Traditional Chinese Medicine.They were divided into treatment group(n = 36)and control group(n = 36)by random number table in a ratio of 1:1 under strict monitoring of vital signs.Among them,the treatment group was treated with traditional Chinese medicine Qingrejiedu Fuzheng Decoction(oral or nasogastric feeding.100 ml/time,3 times/day,all traditional Chinese medicines were purchased uniformly by the department of pharmacy in our hospital and decocted uniformly by the decoction pharmacy),and the control group was treated with Xuebijing injection,a traditional Chinese medicine preparation(10 ml × 5 vials once/day).At the same time,on this basis,the two groups of patients received basic western medicine treatment,the two groups were treated for 11 days.To compare the efficacy and safety of the two groups of medication regimens and provide a reference for clinical usage of medication.Observed and recorded the TCM symptom score,single TCM symptom and the change of inflammatory mediators such as serum WBC,N%,PCT,CRP,IL-1,IL-6 and IL-10 levels before and after treatment,and paid attention to the safety and adverse reactions during treatment.SPSS 2.0 software was used for the analysis and processing of data.Results:(1)Comparison of general data: There was no significant difference in gender,age,and TCM symptom score before treatment between the two groups(P > 0.05),which were comparable.(2)Comparison of inflammatory mediator levels: There were significant differences in serum WBC,N%,PCT,CRP,IL-1,IL-6,and IL-10 levels between the two groups before and after treatment(P < 0.05).There was no significant difference in serum WBC,N%,PCT,CRP,IL-1,IL-6 and IL-10 levels after treatment between the two groups(P > 0.05).(3)Comparison of TCM symptom efficacy: The scores of various TCM symptom scores of the two groups were compared within the group,and it was observed that the scores of aversion to cold,headache,sweating,cough,expectoration,vomiting,diarrhea,fever and accompanying symptoms after treatment were significantly different from those before treatment(P < 0.05).The scores of various TCM symptoms after treatment were compared between the two groups,and it was observed that the scores of aversion to cold and accompanying symptoms were significantly different(P < 0.05),and the treatment group was significantly better than the control group in relieving aversion to cold and accompanying symptoms.The scores of headache,sweating,cough,expectoration,vomiting,diarrhea and fever were not significantly different(P > 0.05),and the therapeutic effects were equivalent.In addition,there was no significant difference in the total score of TCM symptoms after treatment between the two groups(P > 0.05),and the total effective rate when comparing the two groups of data at the same time was the same,suggesting that the treatment group had equivalent efficacy in improving TCM symptoms.(4)Safety analysis: There were no significant changes in vital signs,liver and kidney function,stool routine,and electrocardiogram before and after treatment in both groups,and none of the patients had significant adverse reactions and toxic side effects during the clinical trial observation period.Conclusion: Qingrejiedu Fuzheng Dectoction can significantly reduce the level of serum inflammatory mediators in patients with pulmonary sepsis with heat phlegm and stasis syndrome and significantly alleviate the relevant clinical symptoms of patients with pulmonary sepsis.The effect is obvious with no significant toxicity to the body. |
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