Clinical Research On Postprandial Distress Syndrome Of Spleen Deficiency With Damp Syndrome By JiaWeiSiJunHuoPei Decoction

Research objectives: The main purpose of this study is to observe the clinical effect and reliability of Jiawei Sijun Huopei Decoction for the treatment of postprandial discomfort syndrome(PDS)with syndrome of spleen deficiency and dampness,and provide new methods and clinical treatment ideas for more effective treatment of PDS in Chinese medicine in the future.Research program: Screening patients who were diagnosed with spleen-deficiency and wet-type postprandial discomfort syndrome(PDS)in the Department of Spleen,Stomach,Hepatobiliary Diseases of Yunnan Province Traditional Chinese Medicine Hospital from December 2018 to December 2019.The 72 patients who joined this clinical trial were divided into treatment group and control group 36 cases by random number table method.The decoction given by the treatment group was Jiawei Sijun Huopei Decoction,and the western medicine given by the control group was Mosapride Citrate Tablets.Compare and statistically analyze the efficacy of single TCM syndromes before and after treatment,overall TCM syndrome efficacy,quality of life efficacy,and recurrence of the two groups of patients.Research result: 1.Comparison of therapeutic effects of single TCM syndrome:Before treatment,the scores of the two groups of patients were compared,the difference was not statistically significant(P>0.05);After 4 weeks of treatment,within the group comparison,The difference between the treatment groups was statistically significant(P<0.01);The control group had statistically significant differences in abdominal discomfort,fatigue,fatigue,and limb weight(P<0.01),and eating less and dull,and tasteless(P<0.05),while the stool characteristics changed one Item is not statistically significant,which means that the control group of drugs is ineffective for changing stool characteristics.The comparison between the groups showed that the two symptom scores were P<0.01,and the rest were P<0.05,indicating that the symptoms of the two groups were improved compared with those before treatment,indicating that compared with Mosapride citrate Tablets,Jiawei Sijun Huopei Decoction have the advantages of being full of uncomfortable belly,eating less and dull,light and tasteless,and changing the characteristics of stool.2.Comparison of curative effect of TCM syndromes: The total treatment rates of the treatment group and the control group were 87.50% and 76.67%,respectively.The differentia between both groups was statistically significant(P<0.01).3.Quality of life comparison:Before treatment,the FDDQL scores of the two groups of patients were compared,the difference was not statistically significant(P> 0.05);After the treatment,the comparison was made within the group.The differences in the scores of the individual fields in the treatment group were statistically significant(P <0.01).In the control group,except for the pressure field(P> 0.05),the differences in the scores of the other fields were all Significant statistical significance(P <0.01);Comparing between the groups,except for the health sensory field(P> 0.05)and stress field(0.01 <P <0.05),the differences in the other fields have significant statistical significance(P <0.01),indicating that both treatments can Improve the quality of life of patients,and Jiawei Sijun Huopei Decoction is significantly better than mosapride citrate tablets in improving quality of life.Jiawei Sijun Huopei Decoction is no different from Mosapride Citrate tablets in improving the sense of health,and it is significantly better than Mosapride Citrate tablets in the fields of daily life,worry,diet,sleep,discomfort and disease control.,And has a slight advantage in the field of pressure.4.Comparison of relapses: The relapse rates of the treatment group and the control group after follow-up were 17.2% and 41.7%,respectively.In terms of the long-term efficacy of the two groups,the relapse rate of the treatment group was lower than that of the control group.Research conclusion: Jiawei Sijun Huopei Decoction can significantly improve the clinical manifestations,quality of life,low recurrence rate,good long-term efficacy,no obvious side effects,and high safety in patients with syndromes of spleen deficiency and damp postprandial discomfort syndrome(PDS).This clinical trial will provide richer new methods or treatment ideas for the treatment of PDS with Chinese medicine.