Analysis Of Clinical Data In Children With Non-Alcoholic Fatty Liver Disease And Distribution Of TCM Syndromes

Objective Through the retrospective investigation of non-alcoholic fatty liver disease(NAFLD)in children,analysis of the related risk factors of NAFLD in children,and through cross-sectional investigation to study the distribution characteristics of TCM syndrome types of NAFLD in children.Methods1.171 hospitalized children who were diagnosed as NAFLD during the five years from January 2014 to December 2018 and 120 cases were diagnosed as NAFLD in the outpatient clinic of Wuhan children’s hospital from July to September 2019 were enrolled.At the same time,334 cases with simple obesity were enrolled.2.The clinical data of 171 hospitalized children with NAFLD and 334 hospitalized children with simply obese were collected,including general information(gender,age,BMI,geographical distribution of home address),birth status(birth weight,delivery mode,feeding pattern,whether or not full-term infants),metabolic level(blood pressure,blood lipids,blood glucose,insulin levels,HOMA-IR,glycosylated hemoglobin)and other biochemical indicators(the index of blood routine,the index of liver function level,the index of thyroid function level,sex hormone level).Meanwhile,the demographic data,personal history,exercise condition and syndrome information of TCM of NAFLD children in outpatient clinic were sorted out.3.The index with statistical difference between NAFLD group and simple obesity group was taken as independent variable,and NAFLD as dependent variable was included in regression analysis to establish Logistic regression model.Results1.Univariate analysis shows that the factors related to NAFLD were gender,age,BMI,regional distribution of family address,whether or not full-term infants,blood pressure,TC,TG,LDL-C,HDL-C,postprandial blood glucose(30min,60 min,120min),insulin levels(fasting,30 min,60min,120 min,180min),HOMAIR,glycosy lated hemoglobin,WBC,RBC,HGB,PLT,LYM,MONO,ALT,AST,GGT,AST/ALT,testosterone,dehydroepiandrosterone sulfate.2.In Logistic regression model,age,BMI,regional distribution of family address,postprandial blood glucose(120min),postprandial insulin level(180min)and ALT were independent influencingfactors of NAFLD in obese children.The larger the BMI,the higher the levels of blood glucose and insulin,and the higher the ALT,the greater the risk of NAFLD in prepuberty or pube rtychildren.3.Stomach heat and dampness syndrome is a common syndrome type of NAFLD.In this survey,there were 75 cases,accounting for 62.5%;followed by liver depression and qi stagnationsyndrome,21 cases,accounting for 17.5%;spleen deficiency anddampnes s syndrome,15 cases,accounting for 12.5%;spleen and kidney d eficiency syndrome,only 9 cases,accounting for 7.5%.Conclusions The independent influencing factors of NAFLD included age,BMI,regional distribution of family address,postprandial blood glucose(120min),postprandial insulin level(180min)and ALT.The most common syndrome type of NAFLD is stomach heat and damp ness syndrome,followed by liver depression and qi stagnation syndrome,spleen deficiency and dampness syndrome.