Study On The Relationship Between Blood Lipid With Intestinal Polyps And Adenomas

Background Colorectal polyps are protrusion lesion,which cause by intestinal mucosa epithelial cells abnormal hyperplasia.If don't intervene,it takes about 5-10 years for colorectal polyps to develop into cancer,which has a high mortality.Adenomatous polyp has the greatest potential of malignancy in different types of polyps,which is considered to be an important step in the progress of colorectal cancer..Early detection of polyps,and removing polyps can effectively inhibit the process of polyps to cancer,.The early radical treatment of adenoma has a greater significance to preventing cancer.Patients with colorectal polyps can show different clinical symptoms,but their symptoms are not specific.Digging out the risk factors of polyps and adenomas,stratifying them according to the risk factors,and to guide the targeted screening can improve the detection rate of polyps and adenomas.If reasonable treatment can be given to the controllable risk factors,it may play a role in preventing polyps and adenomas.Currently,it is believed that the nosogenesis of polyps and adenomas is not affected by a single factor,but may be a synergistic mechanism of multiple factors.Dyslipidemia,gender,age and so on may be associated with the pathogenesis of polyps and adenomas.Objective The aim of the study was to analyze whether different levels of Triglyceride(TG),Total Cholesterol(TC),and Low Density Lipoprotein Cholesterol LDL-C)were related with intestinal polyps and adenomas,identify the factors that is likely to associated with colorectal polyps and adenomas,and to determine the risk.Methods Test the levels of TC,TG and LDL-C in venous blood of 880 subjects,blood lipid levels were stratified according to the guidelines(see diagnostic criteria).Divided the 880 subjects into case group(those with polyps according to colonoscopy)and a control group(those without polyps on colonoscopy).The case group was divided into adenoma group and non-adenoma group according to the results of pathological examination.The subjects were divided by age into youth groups(less than 45 years old), middle-aged groups(between 45 to 65 years old)and elderly groups(over 65 years old).To analyze whether there is a correlation between various blood lipid components with colorectal polyps and adenomas,test differences in the proportion of polyps in different age groups and genders and test the difference in the proportion of adenomas in different age groups,genders and polyps positions,and screening out relevant possible factors.Analyzing the possible related factors to found the independent risk factors and risk degree.Results TG is positively related to the development of colorectal polyps,the relationship is close.(r=0.536,P < 0.05).The level of TG is also associated with the location of colorectal polyps(r=0.569,P<0.05).There are significant differences in the prevalence of intestinal polyps between different age groups and different genders(P <0.05).The risk of intestinal polyps is significantly increased in men,which is 4.1 times higher than that in women(OR=4.101,P < 0.05).Middle-aged people are more likely to develop intestinal polyps,and their risk is 1.4 times than that of young people(OR=1.382,P < 0.05).The risk of intestinal polyps increased significantly in older adults,is 3.6 times that in younger adults(OR=3.580,P < 0.05).There are significant differences in the probability of adenomatous polyps in different genders and different locations(P < 0.05).The risk of adenomas is 1.7 times higher in men than in women(OR=1.671,P < 0.05).The risk of adenomas is 3.6 times greater in the colon than in the rectum(OR=3.599,P < 0.05).There is collinearity between TG,TC,LDL-C and age,and they influence each other and have a synergistic effect on the development of polyps.Conclusion TG,age and gender are risk factors for colorectal polyps,and the risk of adenomatous polyps is different in different genders and locations.People with elevated TG levels,those over 40-45 years old and men should pay attention to the screening of colorectal polyps.The polyps of male patients and growing in the colon should be completely cured,and attention should be paid to the postoperative follow-up work.There is a collinear relationship among TG,TC,LDL-C and age,which can synergally promote the incidence of polyps.People with abnormal TG should try their best to control TG at an appropriate level(< 5.2mmol/L)by exercising,adjusting diet or taking lipid-lowering drugs,which has a positive effect on reducing the incidence of polyps.