Linical Analysis Of 693 Cases Of Colorectal Polyps

ObjectiveTo analyse and investigate the risk factors for adenomatous polyp development and polyp recurrence by comparing the general clinical data of patients with colorectal adenomatous polyps and non-adenomatous polyps,with the aim of identifying the population at risk for adenomatous polyp development and polyp recurrence by the more common clinical factors and providing better surveillance.Methods A total of 336 patients with adenomatous polyps and 357 patients with non-adenomatous polyps were included in this study.46 patients in the adenomatous polyp group had recurrence of polyps and 34 patients in the non-adenomatous polyp group had recurrence of polyps.The general data of the two groups were compared,including: gender,age,symptoms,personal history,family history,blood pressure at admission,comorbidities,blood routine,blood biochemistry,tumour markers,CRP and pathological findings of polyps.The survival curves of patients with recurrent adenomatous polyps and non-adenomatous polyps were plotted using the Meier method.Results 1.General clinical information of patients with colorectal adenomatous polyps compared with non-adenomatous polyps: gender(P<0.001),symptoms such as abdominal discomfort and stool changes(P=0.036),history of smoking(P=0.049),history of alcohol consumption(P=0.036),high BMI(i.e.obesity)(P=0.049),combined hyperuricemia(P<0.001),combined fatty liver(P= 0.027),and combined chronic atrophic gastritis(P=0.003)were statistically significant in the adenomatous polyp versus non-adenomatous polyp group,and in the adenomatous polyp group leukocytes(P<0.001),red blood cells(P<0.001),neutrophils(P=0.006),haemoglobin(P<0.001),haematocrit(P<0.001)),AFP(P=0.032)was higher and CRP(P=0.036)was lower than in the non-adenomatous polyp group,with statistically significant differences(P<0.05).2.Comparison of age(P=0.819),history of previous abdominal surgery and/or tumour(P=0.051),family history of tumour(P=0.876),blood pressure at admission(P=0.863 for systolic and P=0.952 for diastolic),combined hypertension(P=0.415),combined diabetes mellitus(P=0.988),combined hyperlipidaemia(P=0.064),combined hyperhomocysteinemia(P=0.807),combined hepatitis B(P=0.162),combined cholecystitis(P=0.382),combined gastric ulcer(P=0.242),combined H.pylori infection(P=0.748),combined gastric polyps(P=0.359),platelets(P=0.950),NLR(P=0.136),RDW-CV(P=0.231),RDW-SD(P=0.738),lymphocyte count(P=0.202),CEA(P=0.812),CA199(P=0.951),CA724(P=0.454),ferritin(P=0.296),ALB(P=0.313),TG(P = 0.426),TC(P=0.417),LDL-C(P=0.569),HDL-C(P=0.718),UA(P=0.088),FBG(P=0.169),TBIL(P=0.783),DBIL(P=0.590),IBIL(P=0.930),AST(P=0.864),and ALT(P=0.118),TBA(P=0.497)were not statistically significant(P>0.05).3.Multi-factorial logistic regression analysis showed that the differences between colorectal adenomatous polyps and non-adenomatous polyps in terms of previous history of tumour and/or abdominal surgery(P=0.031),combined chronic atrophic gastritis(P=0.002),increased red blood cell count(P=0.006),increased AFP(P=0.011)and decreased CRP(P=0.005)were statistically significant(P<0.05).4.Colorectal adenomatous polyps showed statistically significant differences in the number of polyps(P<0.001),polyp site(P<0.001),polyp size(P<0.001)and Paris typing(P<0.001)compared to non-adenomatous polyps.Conclusion 1.Gender,history of smoking,alcohol consumption,abdominal discomfort,changes in bowel habits,previous abdominal surgery or tumour history,combined hyperuricaemia,fatty liver,chronic atrophic gastritis,increased leucocytes,erythrocytes,neutrophils,haemoglobin,haematocrit,increased AFP and decreased CRP may be associated with the development of colorectal adenomatous polyps.2.History of previous tumour and abdominal surgery,combination of chronic atrophic gastritis,high BMI,increased erythrocytes,leucocytes,AFP,and decreased CRP may be independent risk factors for the development of colorectal adenomatous polyps.3.Colorectal adenomatous polyps are more likely than non-adenomatous polyps to have multiple,5-10 mm subtibial polyps occurring in the left hemi-colon.