To Discuss The Effect And Advantage Of Jianpi Tongluo Prescription On CAS Based On The Idea Of Treating Pre-disease

ObjectiveTo explore the theoretical understanding of CAS in Chinese and western medicine and the therapeutic value and advantages of timely intervention of Chinese medicine in CAS,and to observe the clinical effect of jianpi tongluo prescription on CAS.MethodTheoretical study was made by comparing,analyzing and summarizing the relevant papers retrieved in CNKI database,and the classic Chinese medicine books;Clinical research was made by dividing CAS patients into contrast group and treatment group and giving drug treatment of atorvastatin calcium tablets,and atorvastatin calcium tablets combined with Jianpi Tongluo Recipe respectively for 12 weeks.For both groups,the TCM symptoms scores were rated pre-treatment and at 6 wees,12 weeks and 18 weeks post-treatment for both groups;blood lipids(TC,TG,HDL-C,LDL-C),plasma Hey,the inflammatory cytokine hypersensitive C-reactive protein(hs-CRP),the serum plaque stability indicator lipoprotein phospholipase A2(Lp-PLA2),and changes in the liver function indicators(ALT,AST)and renal function indicators(Ure,Cre)were observed pre-treatment and at 12 weeks post-treatment;the adverse reactions during the treatment were also observed.ResultThere were statistically significant differences between the treatment group and control group in the TCM symptoms scores at the end of treatment(Week 12)and at 6 weeks post-treatment(Week 18)(P<0.05).With the exception of dizziness,the scores for each TCM symptom remained decreased in the treatment group compared to the control group at 6 weeks post-treatment(Week 18),with statistically significant differences(P<0.05).The overall response rates at the end of treatment(Week 12)and at 6 weeks post-treatment(Week 18)were 83%and 100%,respectively,in the treatment group,and 60%and 66.7%,respectively,in the control group.In the treatment group,there were different extents of decreases from pre-treatment(Week 0)to end of treatment(Week 12)in TC,TG,and LDL-C(P<0.05),and increase in HDL-C from pre-treatment(Week 0)to end of treatment(Week 12)which showed no statistically significant difference(P>0.05).Compared to the control group,there were greater improvements in TG and HDL-C in the treatment group,with statistically significant differences(P<0.05).In addition,there were significant decreases in hs-CRP,Hcy,and Lp-PLA2 in both groups(P<0.05),and the decreases in Hcy and Lp-PLA2 were greater in the treatment group than in the control group,with statistically significant differences(P<0.05).Conciusion1.In the TCM theory,intermingled phlegm and blood stasis obstructing the cervical vessels is the main etiology of CAS.Early diagnosis and timely intervention for CAS are conducive to the prevention and treatment of cardiovascular and cerebrovascular diseases,which embodies the TCM theory of "preventive treatment of disease".2.Jianpi Tongluo Prescription has well established therapeutic effect,and can effectively improve the clinical symptoms and laboratory markers of CAS.3.Aiming to treat a disease at its primary cause,Jianpi Tongluo Prescription allows for gradual recovery of the organ functions,which is a valid practice of the TCM theory of " preventive treatment of disease".