The Influencing Factors Of Clinical Pregnancy Rate In Intrauterine Insemination

Objective:To explore the influencing factors of clinical pregnancy rate in intrauteri ne insemination(IUI),and to analyze the dates of the infertility patients in the Repr oductive Center of the Affiliated Hospital of Binzhou Medical university from the aspec ts of female’s age,male’s age,body mass index of women(BMI),assisted pregnancy p rogram,endometrium thickness(EMT)on IUI day,the timing of IUI and the post-was h total mobile sperm count(TPMSC).Methods:The retrospective analysis was made on the data of 4066 cycles in 1872 cases of intrauterine insemination in the Reproductive Center of the Affiliated Hospital of Binzhou Medical university from July 2006 to July 2017.According to the different pregnancy outcomes,all the data be segmented into clinical pregnancy group and non-pregnancy group.To observe the differences in the age of female,age of male,BMI of women,endometrial thickness on IUI day and TPMSC injected into uterine cavity every cycle between the two groups.Separate each factor into different groups.The relationship between per factors and clinical outcomes was observed.T-test and Chi-square test were used to analyze the measurement and counting data respectively.The difference was statistically significant with P<0.05.Results:1.With the increase of the couple’s age,The clinical pregnancy rate is less and less satisfactory.(P<0.05).2.No significant effect of endometrial thickness on pregnancy outcome was found in the natural cycle.In the ovarian stimulated cycle,the pregnancy rates in two groups with EMT over 8 mm were higher than EMT below 8 mm(P<0.05).3.IUI frequency:In every cycle,double IUI was better than single IUI(P<0.05).4.IUI timing:The timing before ovulation and after ovulation the next day was better than other timing(P<0.05).5.Pregnancy assistance program:ovulation promotion is more conducive to pregnancy(P<0.05),The program of LE+HMG is the best.6.The TPMSC injected into uterine cavity every cycle has no obvious effect on clinical pregnancy rate(P>0.05).7.No difference in pregnancy rate was found between different BMI groups(P>0.05).Conclusions:1.Age growth is not conducive to pregnancy.2.In natural cycle,EMT was not related to pregnancy outcome.In ovulation induction program,EMT(≥8mm)is benefit to pregnancy.3.Double IUI is better than single IUI in per cycle.In single IUI,there was no effect on the outcome before or after ovulation.IUI can significantly improve pregnancy outcomes before ovulation and after ovulation the next day.before ovulation and after ovulation on the next day is equivalent to single IUI.4.Ovarian stimulation is more beneficial to pregnancy,and letrozole combined with human menopausal gonadotropin is the best drug regime.5.When the TPMSC injected into the uterine cavity within per cycle is less than 5 x 106,a satisfactory pregnancy rate can still be obtained.6.No significant relationship between female BMI and clinical pregnancy rate was found.