Relationship Between Resting Heart Rate And Subclinical Thyroid Dysfunction In Middle-aged And Elderly Population

Objective To study the connection between resting heart rate(RHR)and subclinical thyroid dysfunction in middle-aged and elderly population.Method In this study,the baseline data of "REACTION" and the plus test data of Lanzhou were extracted to study 6,161 eligible residents in Lanzhou community.The data of questionnaire,physical examination and laboratory examination were extracted.The enrolled population was divided into Groups Q1,Q2,Q3,Q4 and Q5 according to gender and RHR quintile.According to the criteria of T3,T4 and TSH,the population were divided into normal thyroid function(normal thyroid function),subclinical hyperthyroidism(subclinical hyperthyroidism)and subclinical hypothyroidism group(subclinical hypothyroidism group).The relationship between RHR and subclinical thyroid dysfunction was investigated by partial correlation analysis,Spearman correlation analysis and Logistic regression analysis.Results1 The mean RHR of the study subjects was 78.1±10.8 times/min,which was higher in females than in males(78.2±10.7 times/min vs 77.4±11.4 times/min,P <0.05).The prevalence of subclinical hypothyroidism was 33.5%,higher in females than in males(P < 0.05),and the prevalence of subclinical hyperthyroidism was 0.4%,higher in females than in males(P < 0.05).2 One-way ANOVA showed that there was no difference in RHR level under different groups of a work status(P all >0.05).As the number of RHR quintile group increased,T3 and T4 levels increased(all P <0.05),and there was no difference in TSH levels between the groups(all P >0.05).3 Covariance analysis showed that before adjusting for confounding factors,there was no difference in RHR level among the total population,the male population and the female population with different a status(all P >0.05).After adjusting forvarious confounding factors,there was still no difference in RHR level among the three groups(all P >0.05).4 Spearman correlation analysis showed that RHR was correlated with T3 level in the total population,male population and female population,with correlation coefficients of 0.089,0.112 and 0.085(all P <0.05),and with T4 level,with correlation coefficients of 0.097,0.127 and 0.090,respectively.In the female population,THE RHR was correlated with TSH level,and the correlation coefficient was-0.030(all P <0.05).There was no correlation between THE RHR and TSH level in the general population and the male population.5 Partial correlation analysis showed that after adjusting for multiple confchors,RHR was correlated with T3 and T4 levels in the total population,with correlation coefficients of 0.060 and 0.088(both P<0.05),and TSH level with correlation coefficient of-0.031(P<0.05).In the female population,RHR was correlated with T3 and T4 levels with a correlation coefficient of 0.050 and 0.075(both P<0.05),and with TSH level with a correlation coefficient of-0.034(P<0.05).In the male population,RHR was correlated with T3 and T4 levels,and the correlation coefficients were 0.091 and 0.140,respectively(all P <0.05).Whether confounding factors were adjusted or not,there was no correlation between RHR and TSH levels in the male population.6 Logistic regression analysis showed that after controlling for various interference factors,total population,male and female RHR were not correlated with the risk of subclinical hypothyroidism or subclinical hyperthyroidism(all P >0.05).Conclusion RHR is positively correlated with T3 and T4 levels in middle-aged and elderly population in Lanzhou,and negatively correlated with TS H levels in female population.RHR was not associated with the risk of subcli nical thyroid dysfunction...