| AIM: The anxiety and depression of patients with Hashimoto’s thyroiditis are more common than that of general patients.Patients with Hashimoto’s thyroiditis often have abnormal thyroid hormone levels and often associated with thyroid nodules,and the emotional factors of Hashimoto’s thyroiditis patients are not very clear.This study investigated the effects of thyroid hormone levels and thyroid nodules on the mood of Hashimoto’s thyroiditis patients.METHODS: From January 2018 to May 2019,114 patients with Hashimoto thyroiditis were selected from outpatient and inpatient department of Endocrinology Department of the first affiliated Hospital of Anhui Medical University as Hashimoto group,which were divided according to different levels of thyroid hormone and whether there were nodules or not;Hashimoto’s patients were divided into Hashimoto’s hyperthyroidism group(HT hyperthyroidism group),Hashimoto’s normal thyroid function group(HT normal group)and Hashimoto’s hypothyroidism group(HT hypothyroidism group)according to thyroid hormone levels.Age,sex,educational level were selected from the physical examination patients,staff and students of our hospital to match the health of the study group people 40 as control group;Hashimoto patients were divided into Hashimoto nodule group and Hashimoto non-tuberculosis group according to whether there were nodules.And 40 healthy patients with age,sex and education matched with the study group were selected as control group from the medical examination patients,staff and students in our hospital.statistical comparison of the values of t3,t4,tsh,tpoab,beck anxiety scale(bai),beck depression scale(bdi)in each group.RESULTS: 1.This patient compared with the normal control general situation: the normal control group gender and Hashimoto group gender between the two groups using chi-square test,P value >0.05,there was no statistical difference between the two groups,data match.The age of the normal control group and the bridge group was tested by independent sample t,P value >0.05,there was no statistical difference between the two groups,and the data were matched.The number of years of education between normal control group and bridge group was compared by independent sample t test,P value >0.05,there was no statistical difference in the number of years of education between the two groups,and the data matched.2.Comparison of T3,T4,TSH and TPOAb levels in each group: compared with the normal control group,T3 and T4 in the HT hypothyroidic group were decreased,while TSH and TPOAb were increased(P<0.05).T3,T4,TPOAb increased and TSH decreased in the HT hyperthyroidism group compared with the normal control group(P<0.05).TPOAb was increased in the normal HT group compared with the normal control group,and there were no statistically significant differences in T3,T4 and TSH(P>,0.05).3.comparison of bai and bdi scores between the bridge group and the normal control group: compared with the bridge group and the normal control group,the overall anxiety score of all ht patients was higher than that of the non-bridge control group(t =5.233,p <0.001).compared with the normal control group,the overall depression score of all ht patients was higher than that of the non-bridge control group(t =5.611,p <0.001).4.The BAI and BDI scores of different thyroid hormone levels were compared among different groups of patients with Hashimoto’s thyroiditis and normal control: the difference of anxiety score of different thyroid hormone levels was statistically significant(P <0.05),the anxiety score of HT hyperthyroidism group was higher than that of normal group(P<0.05),and there was no significant difference of anxiety score among other groups(P >0.05).The scores of different thyroid function depression were statistically significant(P <0.05).The scores of HT normal group were higher than those of normal control group.group(P <0.05),the depression score of HT hypothyroidism group was higher than that of normal control group(P <0.05),the depression score of HT hyperthyroidism group was higher than that of normal control group(P <0.05),and the depression score of HT hyperthyroidism group was higher than that of HT normal group,and there was no significant difference between groups(P >0.05).5.The positive rate of anxiety and depression was compared among groups: the positive rate of anxiety in HT hyperthyroidism group was 30%,higher than that in other groups(P <0.05);the depression rate in HT hyperthyroidism group was 32.5%,higher than that in other groups(P <0.05),and the depression rate in HT hypothyroidism group was 13.8%,higher than that in normal control group and HT normal group(P <0.05).6.different Hashimoto nodule status of human emotion score: different Hashimoto nodule status of the human anxiety score comparison has statistical difference(2=6.930,p=6.0.031),that is,different Hashimoto nodule status of the anxiety score is not complete,further two comparison,Hashimoto nodule score is lower than Hashimoto nodule(p=6.0.028),there is no statistical difference between the other groups.The depression scores of different Hashimoto nodules were statistically different(2=7.727,p=0.026),that is,the depression scores of different Hashimoto nodules were incomplete.There were nodules in the other groups(p =0.025).CONCLUSION: Patients with Hashimoto’s thyroiditis had significant anxiety and depression.The emotional state of patie... |
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