Study On Clinical Effect And Antibacterial Effect Of Qingjin Huatan Decoction On Chronic Obstructive Pulmonary Disease With Acute Exacerbation(Sputum Heat And Lung Syndrome)

Objective:By comparing Qingjin huatan Decoction combined with Western medicine in the treatment of chronic ob structive pulmonary disease with acute exacerbation(Acute Exacerbation of Chronic Obstructive Pulmonary Disease,AE CO PD)(phlegm heat syndrome lung syndrome)before and after treatment,the symptoms and signs scores were combined The killing status of the drug serum on the research strains and a comprehensive evaluation of the clinical therapeutic effect of the drug provide a certain basis for further clarifying the therapeutic effect and mechanism of Qingjin Huatan Decoction on AECOPDMethods:This trial recruited 65 patients who met the standard from the inpatient department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from April 2019 to December 2019,and were grouped according to the random number table method.The treatment group included 32 cases and the control group.In 33 cases,the control group was given conventional basic Western medicine treatment,and the treatment group was given integrated traditional Chinese and western medicine therapy.The control group was given Qingqing Huatan Decoction for 14 days.SPSS 22.0 was used to compare the scores of symptoms and signs before and after treatment,and the bacterial strains cultivated in sputum bacteria during treatment were summarized and the clinical efficacy of the drug treatment was preliminarily judged.To further confirm the results of clinical trials,we conducted in vitro antibacterial experiments based on common strains,and studied the mechanism of action of traditional Chinese medicine compound preparations from the perspective of Chinese medicine serum pharmacologyResults:1.After treatment,the scores of clinical symptoms and signs of patients in the treatment group and the control group showed a downward trend compared with those before treatment The treatment group had statistically significant differences in improving cough,sputum color,thirst,cold drinks,and dry stools,P<0.05,while the differences were not statistically significant in terms of shortness of breath,chest tightness,shortness of breath,fever and chest rales,P>0.05;2.After treatment,the total score of TCM clinical efficacy of the two groups of patients showed a downward trend.Comparing the two groups before and after treatment,and within the group,showed that the total points showed a downward trend,and there was a difference in statistical comparison,P<0.05;3.The effective rate in the treatment group was87.09%,and the marked efficiency was 67.74%.The effective rate in the control group was80.65%,and the marked efficiency was 25.81%.Comparing the apparent efficiency of the two groups,it is concluded that the treatment group is significantly better than the control group in improving the efficiency,and there is a difference in statistical comparison,P<0.05;4.After treatment,the lung function indexes of both groups were improved compared with before treatment.The treatment group had statistically significant differences in improving the forced expiratory volume in 1 second(FE V1%)to the predicted value%and the forced expiratory volume in 1 second(FEV1)and the percentage of occupied vital capacity(FVC)(FEV1/FVC%),P<0.05;while there is no statistical difference between the maximum expiratory flow rate(MEF50)and forced vital capacity(FVC)at 50%improvement in vital capacity,P>0.05;5.Based on the analysis of the bacterial strains cultured from sputum bacteria,the main bacterial strains of patients with chronic obstructive pulmonary disease accompanied by acute exacerbation(phlegm-heat syndrome)include Acinetobacter baumannii(A.baumanii)Staphylococcus(S aureus),Klebsiella pneumoniae(klebsiella),P.aeruginosa(P aeruginosa),etc;6.Qingj in Huatan Decoction only showed a certain bacteriostatic effect on Acinetobacter baumannii,but did not show an effective bacteriostatic effect on other strainsConclusion:1.Qingjin Huatan Decoction combined with conventional Western medicine treatment is significantly better than conventional Western medicine treatment group in improving the clinical symptoms and signs,improving the effective and obvious efficiency,and improving lung function of patients with AECOPD2.The symptoms of patients with AECOPD(phlegm,heat and lung syndrome)have improved,which may be related to the inhibition of Acinetobacter baumannii by Qingjin huatan Decoction-containing serum.