Clinical Analysis Of Primary Colorectal Signet Ring Cell Carcinoma

Objective: The aim of this study was to investigate the clinicopathology features and prognosis of primary colorectal signet-ring cell carcinoma(CSRCC).Methods: Analysis the clinical and survival data of 33 primary colorectal signet-ring cell carcinoma patients who underwent surgical treatment between Jan 2009 and Oct 2018 retrospectively.The cumulative survival rate and mean survival time were estimated according to the method of Kaplan-Meier.The significance of difference in survival rates were calculated using the log-rank test.The multivariate survival analysis was performed by cox regression.Results: The median age of 33 patients was 59±10.5 years,the male to female ratio was 1.36:1.The overall 1,3 and 5-year survival rate after the initial surgery was 66.7%,39.8% and 20%.The mean survival time of 33 patients was 35.97±6.7 months.The mean survival time of patients in stage I/II and III/IV were 84.25±13.6 months and 25.97±5.5 months respectively.Univariate survival analysis showed that TNM stage,T stage,the long diameter of the mass,preoperative intestinal obstruction and surgical methods(endoscopic or open,palliative or radical treatment)were associated with the difference in patient survival(P<0.05).However,the patient’s gender,age,tumor site,postoperative adjuvant therapy and vascular invasion were not correlated(P>0.05).Cox regression analysis showed that preoperative intestinal obstruction,TNM stage and tumor invasion depth were independent prognostic factors(P<0.05).Conclusion: The prognosis of patients with sigmoid ring cell carcinoma of the colorectal is poor.Local progression was late at initial diagnosis,and peritoneal metastases were more common.TNM stage,preoperative intestinal obstruction and tumor invasion depth were independent factors affecting the prognosis of patients,while postoperative radiotherapy and chemotherapy had little impact on their long-term survival.This kind of patients should be paid great attention to,should avoid the late diagnosis of the disease stage and affect their survival.