Clinical Study On The Effect Of Dexmedetomidine On Emergenceagitation Of General Anesthesia In Patients Underwent Thoracoscopic Surgery

Objective: To investigatethe effect of dexmedetomidine on emergenceagitation of general anesthesia in patients underwent thoracoscopic surgery.Methods:The 70 patients who planned to receive elective thoracoscopic surgery were randomly divided into control group(group C)and observation group(group D),35 patients each.Dextromedetomidine 0.1ug/kg/h was intravenously pumped at the beginning of anesthesia induction until the end of surgery in group D,and normal saline of equal volume was intravenously pumped at the beginning of anesthesia induction in group C.The changes of MAP and HR of patients at each time point of T0(entry),T1(30min before the end of surgery),T2(at the end of surgery),T3(at extubation),T4(15min after extubation)and T5(1h after extubation)were recorded.After the operation,the recovery time of spontaneous breathing,opening time of eyes,extubation time,recovery time of directional force and PACU residence time were recorded.patients were given SAS sedation-agitation scores at T3,T4 and T5 time points.Visual analogue scale(VAS)of pain was performed at each time point of T4 and T5 for patients in resting and coughing states.Results: 1.There were no statistically significant differences between the two groups in terms of gender,age,ASA classification,height,weight,BMI value,operation time,anesthesia time,propofol,atropium,ephedrine and urapidil dosage(p>0.05).2.MAP and HR at T1 and T2 time points in the two groups were significantly lower than T0,with statistically significant differences(p<0.05).The HR of group C in T4 and T5 was significantly higher than that in T0,and the difference was statistically significant(p<0.05).The MAP of T4 in group D was significantly lower than that of T0,and the difference was statistically significant(p<0.05).Compared with group C,the MAP of T4 in group D decreased significantly(p<0.05).3.The opening time,extubation time,directional force recovery time and PACU retention time of patients in group D were significantly shorter than those in group C,with statistically significant differences(p<0.05).There was no significant difference in the recovery time of spontaneous breathing between the two groups(p>0.05).There was no statistically significant difference between the two groups in SAS score during postoperative recovery(p>0.05).The emergence agitation rate of group D was 17.1% lower than that of group C,and the difference was statistically significant(p<0.05).The excess sedation rate in group D was20% higher than that in group C,and the difference was statistically significant(p<0.05).There was no significant difference in the satisfaction rate of recovery between the two groups(p>0.05).VAS score in group D was lower than that in group C at the time point T4(p<0.05).There was no statistically significant difference in VAS score between the two groups at other time points and under other conditions(p>0.05).4.The incidence of postoperative chills and respiratory depression in group C was higher than that in group D,with statistically significant differences(p<0.05).There was no statistically significant difference in the incidence of other postoperative adverse reactions between the two groups(p>0.05).Conclusion: Dexmedetomidine 0.1ug/kg/h intraoperative continuous intravenous infusion for thoracoscopic surgery can reduce the incidence of agitation during resuscitation,shorten the resuscitation time,maintain hemodynamic stability during resuscitation,and have no significant adverse reactions.