Effects Of Dexmedetomidine On Hemodynamics And Emergence Agitation In Patients Undergoing Radical Resection Of Colorectal Cancer

Objective:To observe the effect of dexmedetomidine on hemodynamics and emergence agitation in patients undergoing radical resection of colorectal cancer.Methods:A total of 90 patients with laparoscopic radical resection of colorectal cancer were investigated in this study. Patients were randomly divided into two groups, group A (normal saline group) and group B (dexmedetomidine group),45 cases in each group. Patients in group B were infused a loading dosage of dexmetomidine (0.6ug/kg) intravenously 10 min before the induction of general anesthesia followed by continuous infusion [0.3ug/kg/h] for 1 h. Patients in group A were given 0.9% saline solution instead of dexmedetomidine. The patients’hemodynamic parameters, including mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SpO2), cardiac output (CO), stroke volume (SV) and peripheral vascular resistance (SVR), were recorded at the before infusion (TO),1 min after infusion (T1),3 min after infusion (T2),5 min after infusion (T3),7 min after infusion (T4),10 min after infusion (T5), intubation immediately (T6), skin incision (T7), extubation immediately (T8) and 2 min after extubation (T9). Waking time, extubation time and Ricker sedation agitation scale (SAS) during recovery period were recorded and compared between two groups.Results:① Induction period:compared with T0, only MAP、HR and CO decreased significantly at T5 in group B(P<0.05).② Tracheal intubation and skin incision:compared with group A, MAP、HR、CO、 SV and SVR decreased significantly at T6 and T7 in group B(P<0.05).③ Recovery Period:compared with T0, MAP、HR、CO and SV increased significantly at T8 and T9 in group A(P<0.05), and was significantly higher than the data at the same time point in group B. The SAS score in group B was significantly lower than that in group A (P<0.05).Conclusion:For laparoscopic radical resection of colorectal cancer patients, the infusion of dexmedetomidine could reduce the perioperative hemodynamic fluctuations, reduce the stress reaction caused by tracheal intubation and extubation, effectively decrease the incidence of emergence agitation.