| Objective:Analyze the related factors that affect the outcome of early recurrent spontaneous abortion(ERSA),and analyze whether different cut-in timing have an impact on the outcome of abortion in combination with the timing and course of abortion treatment,in order to find the best cut-in timing and reduce or eliminate the impact of related factors on the abortion outcome,to provide clinical reference value in the timing and method selection of abortion,in order to improve the success rate of pregnancy.Method : This study collected retrospective studies from December 2014 to December 2019 with previous cases of ERSA and re-pregnancy in the gynecological inpatient department of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine(TCM)for retrospective studies.353 cases were followed up to≥12weeks of pregnancy.According to the final abortion outcome,they were divided into237 cases of success and 116 cases of failure.The age,BMI,previous pregnancy history,menstrual conditions,TCM syndrome,thyroid function and Data of islet function laboratory test results,time to start treatment,and duration of treatment were entered into Excel and statistically analyzed using SPSS 25.0 software.Result:1.Of the 353 patients with ERSA in this study,237 cases(67.14%)were successful and 116 cases(32.86%)failed.2.The age,menarche age,and body mass index(BMI)of patients with ERSA have an statistically significant effect on the abortion outcome(P<0.05);Patients with age ≥35years old,menarche age ≥16 years old,and overweight or obese have a lower success rate of abortion(P<0.05).3.The number of pregnancies,spontaneous abortions,abortion and biochemical pregnancies in patients with ERSA have an impact on the abortion outcome and have statistical significance(P<0.05).The fetal success rate gradually decreased with the increase of the number of times.4.In this study,the distribution of TCM syndromes of patients with ERSA in this study is as follows: kidney deficiency syndrome> spleen and kidney deficiency syndrome> blood stasis syndrome> blood heat syndrome> qi and blood deficiency syndrome.Patients with kidney deficiency syndrome had a higher success rate of abortion,and from 4 to 5 weeks of pregnancy,the success rate of abortion was higher(P<0.05),patients with blood stasis syndrome had a low success rate of abortion(P<0.05).5.The abortion rate of patients with ERSA combined with hypothyroidism decreased(P<0.05),and thyroid stimulating hormone(TSH)had an effect on the outcome of abortion.With a TSH of 0.1 to 2.5 m IU / L,the success rate of abortion is higher.When TSH ≥ 2.5 m IU / L,as the TSH value increases,the success rate of abortion decreases gradually(P<0.05).The abortion rate of patients with ERSA combined with abnormal islet dysfunction decreased(P<0.05).6.This study initially found that among the 353 patients with ERSA,the number of treatment days in the successful abortion group was greater than that in the abortion group(P<0.05),and had a higher rate of successful abortion from the <6 weeks of pregnancy and had statistical significance(P<0.05).7.The success rate of ERSA patients with more than 3 spontaneous abortions is higher when they start treatment from 4 to 5 weeks of gestation,which is statistically significant(P<0.05).Conclusion:1.Old age,overweight or obesity,menarche age ≥ 16 years old,too many times of abortion / natural abortion / biochemical pregnancy can all reduce the success rate of abortion.Patients with ERSA of kidney deficiency syndrome have a higher success rate of abortion,and if they have blood stasis syndrome,the rate of abortion is lower.2.Hypothyroidism,and dysfunction of islets of Langerhans in patients with ERSA will affect the outcome of abortion.When TSH ≥ 2.5miu/l,the success rate decreased with the increase of TSH.3.Early recurrent miscarriage patients with kidney deficiency syndrome,isletfunction abnormalities,and spontaneous abortions≥3 times can improve the outcome of abortion.For example,the success rate of abortion is higher from 4 to 5 weeks of pregnancy. |
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