Depression And Anxiety Of Patients After Coronary Artery Intervention And The Effect Of Deanxit Intervening On Anxiety And Depression

Background: Coronary atherosclerosis is a major disease that threatens human health and is the most common cause of death worldwide.The number of patients with cardiovascular disease will still show a rapid growth trend in the next ten years,and cardiovascular disease will become a major public health problem.At present,percutaneous coronary intervention(PCI)has become an important treatment method for coronary heart disease and has achieved good results because of its advantages such as less trauma,shorter treatment period,and significantly improved ischemic symptoms.Studies have shown that more and more patients with coronary heart disease experience anxiety and depression after receiving PCI,which has a negative impact on patients’ prognosis.There are many factors that will affect the incidence of anxiety and depression in patients after PCI.At present,there are few methods for judging and evaluating psychological disorders after coronary stent,and there is no uniform standard at present.There is no fixed model for the treatment of psychological disorders after coronary stenting.What’s more,the intervention measures for patients with PCI diagnosed as anxiety or depression have not yet been determined.Objective: To evaluate the impact of existing data on anxiety and depression in patients after PCI,and to apply a new and concise general hospital self-assessment scale for psychological status to the Zung self-assessment scale for depression and anxiety(SAS,SDS).To evaluate the accuracy and simplicity of diagnosis of psychological disorders in patients undergoing PCI for the first time,and to verify the reliability and feasibility of using it as a standard diagnostic method for psychological disorders related to coronary intervention;(2)To verify the effectiveness of Deanxit(flupentixol and melitrizine tablets)in the treatment of psychological intervention-related psychological disorders.Methods: A total of 243 patients who were firstly treated with PCI in the fifth department of Cardiology in the Second Hospital of Hebei Medical University from September 2019 to December 2019 were selected.After the patients’ consent,the Psychological Self-Assessment Scale of General Department of Cardiology was used.On the first and second day after PCI,patients were assessed with different self-assessment scales for psychological status evaluation(for those who cannot fill in the information independently,the researcher should read it and the patient chooses it).Patients diagnosed with mild to moderate anxiety / depression diagnosed with the Zung self-rating anxiety and depression scale were randomly divided into the Darixin group and the control group.The patients in the control group were only given conventional medication after PCI and health education during the hospital.Patients in the new group took Deanxit on the basis of the control group without taking any other anxiolytic and depression drugs during the course of 30 days.After 30 days of treatment,the clinical symptoms,signs,heart rate,blood pressure,electrocardiogram of the patients were observed,and SAS and SDS scores were performed.Data were processed using SPSS23.0 statistical software.Measurement data that conformed to the normal distribution was expressed as mean ± standard deviation.Comparisons between groups were performed using t test,univariate analysis was performed using χ~2 test,and multivariate analysis was performed using ordered multiple logistic regression analysis.The feasibility of the self-assessment scale for the psychological status of the general department of cardiology in the general hospital was analyzed using the Pearson product-related reliability and validity.P <0.05 was considered statistically significant.Results: 243 patients were evaluated using the SAS self-assessment scale.A total of 55 patients had anxiety,of which 39(16%)had mild anxiety,15(6.2%)had moderate anxiety,and 1(0.4%)The self-evaluation results of the patients were severe anxiety.243 patients were evaluated using the SDS self-assessment scale,of which 25(10.3%)patients had mild depression and 34(14%)patients had moderate depression.Diagnosis,drinking history,and education background all have an impact on anxiety and depression in patients after PCI,and family history of coronary heart disease has an effect on depression in patients after PCI.The self-assessment scales of general hospitals’ psychological status were significantly related to the SAS and SDS self-assessment scales(Pearson correlations were 0.825 and 0.875,respectively).The score of the Deanxit group showed a downward trend,and the difference was statistically significant compared with the control group,P <0.001.The total effective rates of angina pectoris and electrocardiogram were 89.74% and 82.05%,which were significantly higher than those of the control group.P<0.05.The incidence of adverse reactions of Deanxit was 5.13%.Conclusions: 1.Anxiety and depression are easy to occur in patients after coronary artery intervention,and the degree of anxiety and depression is mostly mild to moderate.2.Patients diagnosed with acute ST-elevation myocardial infarction,long-term drinking history,and low education level are more likely to have anxiety and depression after PCI;family history of coronary heart disease is positively correlated with depression.3.The self-assessment scale of the psychiatric department of the general hospital has a high consistency with the Zung self-assessment scale of anxiety and depression.4.On the basis of regular anti-myocardial ischemia treatment,Deanxit can significantly improve the psychological state of patients with anxiety and depression after PCI.