Effects Of Application Of Growth Hormone In Hormone Replacement Protocol On The Outcome Of Frozen Embryo Transfer

Objective: To analyze whether the application of growth hormone in the frozen embryo transplantation(FET)cycle can improve the pregnancy outcome of the patients.Methods: There was a retrospective study with 918 patients(1042 cycles)who accepted frozen embryo transfer in the Fourth Hospital of Hebei Medical University Department of Reproductive Medicine from January 2015 to July 2018.To analyse the factors those affected the pregnancy rate in frozen embryo transfer cycles and whether growth hormone was one of the affected factors.Patients were divided into two groups according to whether combining with growth hormone in the hormone replacement protocol: group A(used growth hormone group)and group B(unused growth hormone group).The embryo implantation rate,the clinical pregnancy rate,the abortion rate and the live birth rate were compared between the two groups in the first time FET patients,aged patients,PCOS patients and recurrent implantation failure patients.Results: The age of the patients was the factor that affected the clinical pregnancy rate of FET.The application of growth hormone was the factor that affected the clinical pregnancy rate of recurrent implantation failure patients.There were no significant differences in the embryo implantation rate,the clinical pregnancy rate,the abortion rate and the live birth rate between group A and group B in the first time FET patients and elder patients(P>0.05).In PCOS patients,the live birth rate in group A is significantly higher than that in group B,and the abortion rate is significantly lower than that in group B(P<0.05),but there were no significant differences in the implantation rate and the clinical pregnancy rate between the two groups(P>0.05).In the recurrent implantation failure patients,the implantation rate,the clinical pregnancy rate and the live birth rate in group A were significantly higher than those in group B(P<0.05),and there was no significant difference in the abortion rate between the two groups(P>0.05).Conclusion:1.The factors that affect the clinical pregnancy rate of the hormone replacement FET cycle include the patient's age and the application of growth hormone.2.For the recurrent implantation failure patients,the application of growth hormone could increase the implantation rate,clinical pregnancy rate and live birth rate.3.The application of growth hormone in PCOS patients could reduce the abortion rate and increase the live birth rate.