| Objective To investigate the incidence rate and related risk factors,characteristics,clinical manifestations,endoscopic findings,diagnosis and treatment,follow-up and prognosis of inflammatory bowel disease in Affiliated Hospital of Inner Mongolia Medical University in the Inner Mongolia Autonomous Region,provide reliable regional information for basic and clinical research of inflammatory bowel disease in China,and provide guidance for diagnosis and treatment strategy of inflammatory bowel disease in Inner Mongolia.Methods From January 2008 to January 2018,the clinical diagnosis and treatment data of the first confirmed inpatients with ulcerative colitis and Crohn’s disease were retrieved through the medical cloud medical data intelligent platform of our hospital,and the epidemiology and clinical characteristics of inflammatory bowel disease were studied retrospectively.In the study,Microsoft Excel was used to establish the database,and the medical records that met the inclusion criteria were entered and the data were counted.SPSS17.0 software was used to analyze the data.The measurement data was expressed by(x± s),and the comparison between groups was made by t test;the counting data was expressed by rate(%),and the comparison was made by χ 2 test.The difference was statistically significant(P < 0.05).Results During the 10 years from January 1,2008 to January 1,2018,426 newly diagnosed IBD patients were hospitalized in our hospital,including 352 UC patients and 74 CD patients.The average age of UC patients was(50.23 ± 15.18)years,CD patients was(49.57 ± 18.09)years,the age of onset was similar,the difference was not statistically significant(t = 0.328,P = 0.743).The sex ratios of UC and CD patients were 1.35:1(202 /150)and 1.47:1(44 / 30),respectively,with no significant difference(χ 2 = 0.108,P = 0.743).In UC,37.22%(131 / 352)patients had different types of disease history,and in CD,28.38%(21 / 74)patients had different types of disease history.There was no difference between the two groups in the proportion of previous disease history(χ 2 = 2.081,P = 0.149).In UC patients,22.44%(79 / 352)had previous abdominal operation history,and in CD patients,33.78%(25 / 74)had previous abdominal operation history.The difference was statistically significant(χ 2 = 4.262,P = 0.039).The proportion of CD patients with previous abdominal operation history was higher than that of UC patients.During the past 10 years,UC in the top three departments were digestive medicine,gastrointestinal surgery and Mongolian medicine,and Cd in digestive medicine,gastrointestinal surgery and hepatobiliary,pancreatic and splenic surgery.Although epidemiological survey shows that the incidence rate of IBD is increasing year by year.However,the proportion of UC and CD hospitalization and the proportion of total hospitalization in the whole hospital in January 1,2008 to January 1,2018 has not increased year by year(=1.02,P > 0.05),which may be related to the lack of clinical doctors’ recognition of the disease and the low clinical diagnosis rate.IBD is characterized by fever,emaciation,anemia,hypoproteinemia and electrolyte disorder.The gastrointestinal tract is characterized by abdominal pain,diarrhea,bloody stool,mucinous stool,purulent bloody stool or mucopurulent bloody stool,abdominal distention,anorexia,acid regurgitation,heartburn,nausea,vomiting,urgency and weight loss.Hemorrhoids,anal fissure,and perianal abscess can be seen in perianal lesions,and oral cavity is mainly involved in extraintestinal manifestations,Skin,eyes and peripheral joints.Aminosalicylic acid,glucocorticoid,microbial agents and antibiotics are the most frequently used in IBD treatment,immunosuppressants are less used,while biological agents have not been used in this study,which may be related to factors such as less patients in severe active period,low use rate of biological agents and limited doctors’ knowledge of drugs.During the study period,the recurrence rate of UC patients was 18.75%(66 / 352),CD patients was 12.16%(9/ 74).There was no significant difference between UC and CD patients(χ 2 = 1.829,P =0.176).The incidence of complications was 6.53%(23 / 352)in UC patients and 18.92%(14/ 74)in CD patients.The difference was statistically significant(χ 2 = 11.825,P = 0.001).Conclusion The incidence rate of inflammatory bowel disease is increasing year by year,and the disease is long,and the disease is repeated.It is difficult to cure and is prone to multiple complications,which seriously affects the quality of life.In clinical work,doctors should strictly grasp the diagnostic points of inflammatory bowel disease,improve the rate of diagnosis,and detect and treat the disease as soon as possible,thereby reducing the social and economic burden and improving the quality of life of patients. |
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